N-<4-(bromoacetyl)phenyl>-1,2-dideoxy-1-<3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl>-β-D-erythro-pentofuranuronamide

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Chemical Name:N-<4-(bromoacetyl)phenyl>-1,2-dideoxy-1-<3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl>-β-D-erythro-pentofuranuronamide
CAS No.:89196-52-1
Molecular Formula:C₁₈H₁₈BrN₃O₆
Molecular Weight:452.261
Hs Code.:

Synonyms:N-<4-(bromoacetyl)phenyl>-1,2-dideoxy-1-<3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl>-β-D-erythro-pentofuranuronamide

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Chemical Property of N-<4-(bromoacetyl)phenyl>-1,2-dideoxy-1-<3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl>-β-D-erythro-pentofuranuronamide

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Technology Process of N-<4-(bromoacetyl)phenyl>-1,2-dideoxy-1-<3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl>-β-D-erythro-pentofuranuronamide

There total 4 articles about N-<4-(bromoacetyl)phenyl>-1,2-dideoxy-1-<3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl>-β-D-erythro-pentofuranuronamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 80647-04-7
N-<4-(chloroacetyl)phenyl>-1,2-dideoxy-1-<3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl>-β-D-erythro-pentofuranuronamide

: 89196-52-1
N-<4-(bromoacetyl)phenyl>-1,2-dideoxy-1-<3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl>-β-D-erythro-pentofuranuronamide

Guidance literature:: With sodium bromide; In acetone; for 68h; Ambient temperature;
DOI:10.1021/jm00371a022

Reference yield:

: 2705-89-7
2-(p-aminophenyl)-2-(chloromethyl)-1,3-dioxoloane

: 89196-52-1
N-<4-(bromoacetyl)phenyl>-1,2-dideoxy-1-<3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl>-β-D-erythro-pentofuranuronamide

Guidance literature:: Multi-step reaction with 3 steps

1: 34 percent / triethylamine, diphenylphosphoryl azide / dimethylformamide / 20 h / Ambient temperature

2: 84 percent / 0.1 N aq. HCl / ethanol / 1.5 h / Heating

3: 73 percent / NaBr / acetone / 68 h / Ambient temperature

With hydrogenchloride; diphenylphosphoranyl azide; triethylamine; sodium bromide; In ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00371a022

Reference yield:

: 3544-99-8
thymidine-5'-carboxylic acid

: 89196-52-1
N-<4-(bromoacetyl)phenyl>-1,2-dideoxy-1-<3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl>-β-D-erythro-pentofuranuronamide

Guidance literature:: Multi-step reaction with 3 steps

1: 34 percent / triethylamine, diphenylphosphoryl azide / dimethylformamide / 20 h / Ambient temperature

2: 84 percent / 0.1 N aq. HCl / ethanol / 1.5 h / Heating

3: 73 percent / NaBr / acetone / 68 h / Ambient temperature

With hydrogenchloride; diphenylphosphoranyl azide; triethylamine; sodium bromide; In ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00371a022