(4R)-4-(2-benzyloxy-1,1-dimethylethyl)-1-(4-methoxyphenyl)azetidine-2,3-dione

Base Information

Chemical Name:(4R)-4-(2-benzyloxy-1,1-dimethylethyl)-1-(4-methoxyphenyl)azetidine-2,3-dione
CAS No.:957791-56-9
Molecular Formula:C₂₁H₂₃NO₄
Molecular Weight:353.418
Hs Code.:

Synonyms:(4R)-4-(2-benzyloxy-1,1-dimethylethyl)-1-(4-methoxyphenyl)azetidine-2,3-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R)-4-(2-benzyloxy-1,1-dimethylethyl)-1-(4-methoxyphenyl)azetidine-2,3-dione

Chemical Property:

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Technology Process of (4R)-4-(2-benzyloxy-1,1-dimethylethyl)-1-(4-methoxyphenyl)azetidine-2,3-dione

There total 7 articles about (4R)-4-(2-benzyloxy-1,1-dimethylethyl)-1-(4-methoxyphenyl)azetidine-2,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 865154-57-0
(3S,4R)-4-(2-benzyloxy-1,1-dimethylethyl)-3-hydroxy-1-(4-methoxyphenyl)azetidin-2-one

: 957791-56-9
(4R)-4-(2-benzyloxy-1,1-dimethylethyl)-1-(4-methoxyphenyl)azetidine-2,3-dione

Guidance literature:: With phosphorus pentaoxide; In dimethyl sulfoxide; at 20 ℃; for 24h;
DOI:10.1016/j.tetasy.2007.08.012

Reference yield:

: 776-88-5
5,5-dimethyl-2-phenyl-[1,3]dioxane

: 957791-56-9
(4R)-4-(2-benzyloxy-1,1-dimethylethyl)-1-(4-methoxyphenyl)azetidine-2,3-dione

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / lithium aluminum hydride; aluminum chloride / diethyl ether; CH₂Cl₂

2: 92 percent / oxalyl chloride; dimethyl sulfoxide; triethylamine / CH₂Cl₂ / -60 - 20 °C

3: 95 percent / molecular sieves 4 Angstroem / CH₂Cl₂ / 2 h / 20 °C

4: 75 percent / triethylamine / CH₂Cl₂ / -10 - 20 °C

5: 47 percent / Amano PS lipase / aq. phosphate buffer; acetonitrile / 72 h / 20 °C / pH 7.5

6: 55 percent / phosphorus pentoxide / dimethylsulfoxide / 24 h / 20 °C

With phosphorus pentaoxide; lithium aluminium tetrahydride; aluminium trichloride; oxalyl dichloride; 4 A molecular sieve; Amano PS Lipase; dimethyl sulfoxide; triethylamine; In phosphate buffer; diethyl ether; dichloromethane; dimethyl sulfoxide; acetonitrile; 2: Swern oxidation;
DOI:10.1016/j.tetasy.2007.08.012

Reference yield:

: 957791-54-7
(E)-N-(3-(benzyloxy)-2,2-dimethylpropylidene)-4-methoxybenzenamine

: 957791-56-9
(4R)-4-(2-benzyloxy-1,1-dimethylethyl)-1-(4-methoxyphenyl)azetidine-2,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / triethylamine / CH₂Cl₂ / -10 - 20 °C

2: 47 percent / Amano PS lipase / aq. phosphate buffer; acetonitrile / 72 h / 20 °C / pH 7.5

3: 55 percent / phosphorus pentoxide / dimethylsulfoxide / 24 h / 20 °C

With phosphorus pentaoxide; Amano PS Lipase; triethylamine; In phosphate buffer; dichloromethane; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/j.tetasy.2007.08.012