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Usage

Uses

Used in Fragrance and Flavor Industry:
5,5-Dimethyl-2-phenyl-1,3-dioxane is used as a key ingredient in the creation of fragrances and flavors due to its appealing scent, enhancing the sensory experience of various consumer products.
Used as an Industrial Solvent:
In various industrial applications, 5,5-dimethyl-2-phenyl-1,3-dioxane serves as a solvent, facilitating processes that require the dissolution of other substances for manufacturing purposes.
Used in Pharmaceutical Industry:
5,5-Dimethyl-2-phenyl-1,3-dioxane has potential applications within the pharmaceutical sector, where it may be utilized in the development or production of medicinal compounds.
Used as a Precursor in Organic Synthesis:
5,5-dimethyl-2-phenyl-1,3-dioxane also functions as a precursor for the synthesis of other organic compounds, contributing to the creation of a range of chemical products.
It is crucial to handle 5,5-dimethyl-2-phenyl-1,3-dioxane with care due to its potential health risks upon exposure, ensuring safety in all applications.

InChI:InChI=1/C12H16O2/c1-12(2)8-13-11(14-9-12)10-6-4-3-5-7-10/h3-7,11H,8-9H2,1-2H3

Upstream product

• 100-52-7 benzaldehyde 
• 126-30-7 2,2-Dimethyl-1,3-propanediol 
• 772-01-0 2-phenyl-1,3-dioxane 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 6296-95-3 1,1,2-triphenyl-1,2-ethanediol 
• 579-43-1 (1S,2R)-1,2-diphenylethane-1,2-diol 
• 1439-07-2 trans-Stilbene oxide 
• 100-51-6 benzyl alcohol 
• 62999-86-4 5,5-Dimethyl-2-N,N-dimethylamino-1,3-dioxane 
• 65849-85-6 3,3,9,9-Tetramethyl-1,5,7,11-tetraoxaspiro<5.5>undecan 
• 583-60-8 2-Methylcyclohexanone 
• 774-48-1 (diethoxymethyl)benzene 
• 103-82-2 phenylacetic acid 
• 599-67-7 1,1-diphenylethanol 

Downstream Products

• 38216-93-2 3-benzyloxypivalic aldehyde 
• 772-01-0 2-phenyl-1,3-dioxane 
• 66582-32-9 3-(benzyloxy)-2,2-dimethylpropan-1-ol 
• 70659-74-4 3-bromo-2,2-dimethylpropyl benzoate 
• 10503-36-3 exo-7-phenyl-norcarane 
• 10503-37-4 7-phenylbicyclo[4.1.0]heptane 
• 100-52-7 benzaldehyde 
• 36881-14-8 3-(benzyloxy)-2,2-dimethylpropionic acid 
• 65-85-0 benzoic acid 
• 5522-92-9 2,2-dimethyl-1,3-propanediol 1-benzoate 
• 957791-54-7 (E)-N-(3-(benzyloxy)-2,2-dimethylpropylidene)-4-methoxybenzenamine 
• 957791-46-7 (3R,4S)-3-acetoxy-4-(2-benzyloxy-1,1-dimethylethyl)-1-(4-methoxyphenyl)azetidin-2-one 
• 865154-57-0 (3S,4R)-4-(2-benzyloxy-1,1-dimethylethyl)-3-hydroxy-1-(4-methoxyphenyl)azetidin-2-one 
• 865154-54-7 (3R,4S)-3-hydroxy-4-(2-benzyloxy-1,1-dimethylethyl)-1-(4-methoxyphenyl)azetidin-2-one 

Relevant academic research and scientific papers

Evaluation of the Pharmacophoric Role of the O-O Bond in Synthetic Antileishmanial Compounds: Comparison between 1,2-Dioxanes and Tetrahydropyrans

Leishmaniases are neglected diseases that can be treated with a limited drug arsenal; the development of new molecules is therefore a priority. Recent evidence indicates that endoperoxides, including artemisinin and its derivatives, possess antileishmanial activity. Here, 1,2-dioxanes were synthesized with their corresponding tetrahydropyrans lacking the peroxide bridge, to ascertain if this group is a key pharmacophoric requirement for the antileishmanial bioactivity. Newly synthesized compounds were examined in vitro, and their mechanism of action was preliminarily investigated. Three endoperoxides and their corresponding tetrahydropyrans effectively inhibited the growth of Leishmania donovani promastigotes and amastigotes, and iron did not play a significant role in their activation. Further, reactive oxygen species were produced in both endoperoxide-and tetrahydropyran-Treated promastigotes. In conclusion, the peroxide group proved not to be crucial for the antileishmanial bioactivity of endoperoxides, under the tested conditions. Our findings reveal the potential of both 1,2-dioxanes and tetrahydropyrans as lead compounds for novel therapies against Leishmania.

Graphene-catalyzed transacetalization under acid-free conditions

1,2- and 1,3-Diols are readily protected as cyclic acetals and ketals through a graphene-catalyzed transacetalization process. The methodology features an atom economic procedure since quasi-stoichiometric conditions have been developed. Unlike prior systems, the graphene-catalyzed transacetalization is performed under Br?nsted and Lewis acid-free conditions and without solvent. Our method has been applied to several volatile compounds that are unsuitable for complex work-up and extensive purification steps. The very unusual catalytic properties of graphene for transacetalization reactions are ascribed to molecular charge transfer between graphene and substrates.

Phosphorus promoted SO42-/TiO2 solid acid catalyst for acetalization reaction

A novel phosphorus modifed SO42-/TiO2 catalyst was synthesized by a facile coprecipitation method, followed by calcination. The catalytic performance of this novel solid acid was evaluated by acetalization. The results showed that the phosphorus was very effcient to enhance the catalytic activity of SO42-/TiO2. The solid acid owned high activity for the acetalization with the yields over 90%. Moreover, the solid acid could be reused for six times without loss of initial catalytic activities.

Rapid assessment of protecting-group stability by using a robustness screen

An experimentally simple method has been developed to rapidly establish the stability of widely utilized silyl, acetal, and carbamate protecting groups to a given set of reaction conditions. Assessment of up to twelve protecting groups in a single experiment has been demonstrated. Evaluation of this protocol in two unrelated synthetic transformations suggests that this method can be used to select appropriate protecting groups in the design of synthetic routes.

Four acid-catalysed dehydration reactions proceed without interference

Four acid-catalysed dehydration reactions can proceed in one pot, simultaneously and without interference, to yield one imine, one acetal (or boronic ester), one ester and one alkene, even though many other cross-products could be conceived. This advanced

Facile aldolization catalyzed by ionic liquid [4-sulfbmpyrazine][BF 4]

The acidic functionalized ionic liquid 1-(4-sulfonic group)butyl-3- methylpyrazine tetrafluoroborate (abbreviated as [4-sulfbmpyrazine][BF 4]) was employed as the catalyst of the condensation of aromatic aldehyde and diols. The optimized condition was as follows: aromatic aldehyde (0.20 mol), diols (0.30 mol) and [4-sulfbmpyrazine][BF4] (0.60 g) were refluxed in cyclohexane (10.00 mL) for 1 h. A series of aromatic aldehydes were studied and afforded the corresponding acetals products with good yields which were from 70.3 to 96.9 %. The ionic liquid catalyst could be recycled for four times without significant loss of catalyst reactivity.

Synthesis of a novel melamine-formaldehyde resin-supported ionic liquid with Bronsted acid sites and its catalytic activities

Bronsted acidic ionic liquid immobilized on a melamine-formaldehyde resin (AIL-MFR) was synthesized through the reaction of melamine-formaldehyde resin (MFR) with 1,4-butanesulfonate. Using PEG-2000 as the additive, the MFR can be prepared in regular microspheres with an average diameter of 3.97 μm and surface area of 9.09 m2 g-1. The AIL-MFR had high acidity of 2.93 mmol g-1, mainly from the sulfonic groups. The catalysis results showed that the AIL-MFR had high activity and stability for acetalization with excellent conversions and yields for most substrates. Furthermore, immobilization of the acidic ionic liquid on the MFR made the recycling of the catalyst convenient.

Synthesis of novel solid acidic ionic liquid polymer and its catalytic activities

The novel solid acidic ionic liquid polymer has been synthesized through the copolymerization of acidic ionic liquid oligomers and resorcinol- formaldehyde (RF resin). The catalytic activities were investigated through the acetalization. The results showed that the PIL was very efficient for the reactions with the average yield over 99.0%. The procedure was quite simple with just one-step to complete both the reactions. The high hydrophobic BET surface, high catalytic activities and high stability gave the PIL great potential for green chemical processes. Pleiades Publishing, Ltd., 2013.

Polyacrylonitrile fiber mat supported solid acid catalyst for acetalization

A novel polyacrylonitrile hybrid fiber mat supported solid acid catalyst was prepared by electrospin-ning, and its catalytic activities were carefully investigated through acetalization reactions. The results showed that this hybrid fiber mat exhibits high activity for the reactions, with average yields over 95%. Besides having catalytic activities similar to the solid acid, the heterogeneous solid acid/polyacrylonitrile mat can be reused in six runs without significant loss of catalytic activities. The large size of the hybrid fiber mat greatly facilitates recovery of the catalyst from the reaction mixture. The high and stable catalytic activities of the hybrid fiber mat hold great potential for green chemical processes and preparation of membrane reactors in the future.

Efficient and chemoselective acetalization and thioacetalization of carbonyls and subsequent deprotection using InF3 as a reusable catalyst

An efficient and chemoselective method for preparation of acetals and dithioacetals of aldehydes and their deprotection under catalysis of InF 3 is described.