776-88-5

Basic information

• Product Name: 5,5-dimethyl-2-phenyl-1,3-dioxane
• Synonyms: 5,5-dimethyl-2-phenyl-1,3-dioxane;2-Phenyl-5,5-dimethyl-1,3-dioxane;Benzaldehyde (2,2-dimethylpropane-1,3-diyl)acetal;Benzaldehyde 2,2-dimethylpropane-1,3-diyl acetal;Benzaldehyde 2,2-dimethyltrimethylene acetal
• CAS NO: 776-88-5
• Molecular Formula: C₁₂H₁₆O₂
• Molecular Weight: 192.25424
• EINECS: 212-284-5
• Mol File: 776-88-5.mol
• Article Data: 35

Chemical Properties

• Boiling Point: 269.7°C at 760 mmHg
• Flash Point: 121.7°C
• Appearance: /
• Density: 1.005g/cm³
• Vapor Pressure: 0.0119mmHg at 25°C
• Refractive Index: 1.491
• CAS DataBase Reference: 5,5-dimethyl-2-phenyl-1,3-dioxane(CAS DataBase Reference)
• NIST Chemistry Reference: 5,5-dimethyl-2-phenyl-1,3-dioxane(776-88-5)
• EPA Substance Registry System: 5,5-dimethyl-2-phenyl-1,3-dioxane(776-88-5)

Safety Data

• Hazardous Substances Data: 776-88-5(Hazardous Substances Data)

Usage

Description

5,5-Dimethyl-2-phenyl-1,3-dioxane is a cyclic ether chemical compound with the molecular formula C11H16O2. It features a six-membered dioxane ring structure with two oxygen atoms and two alkyl substituents, presenting as a colorless liquid. 5,5-dimethyl-2-phenyl-1,3-dioxane is recognized for its pleasant odor, making it suitable for use in the production of fragrances and flavors.

Uses

Used in Fragrance and Flavor Industry:
5,5-Dimethyl-2-phenyl-1,3-dioxane is used as a key ingredient in the creation of fragrances and flavors due to its appealing scent, enhancing the sensory experience of various consumer products.
Used as an Industrial Solvent:
In various industrial applications, 5,5-dimethyl-2-phenyl-1,3-dioxane serves as a solvent, facilitating processes that require the dissolution of other substances for manufacturing purposes.
Used in Pharmaceutical Industry:
5,5-Dimethyl-2-phenyl-1,3-dioxane has potential applications within the pharmaceutical sector, where it may be utilized in the development or production of medicinal compounds.
Used as a Precursor in Organic Synthesis:
5,5-dimethyl-2-phenyl-1,3-dioxane also functions as a precursor for the synthesis of other organic compounds, contributing to the creation of a range of chemical products.
It is crucial to handle 5,5-dimethyl-2-phenyl-1,3-dioxane with care due to its potential health risks upon exposure, ensuring safety in all applications.

InChI:InChI=1/C12H16O2/c1-12(2)8-13-11(14-9-12)10-6-4-3-5-7-10/h3-7,11H,8-9H2,1-2H3

Upstream product

• 126-30-7 2,2-Dimethyl-1,3-propanediol 
• 1439-07-2 trans-Stilbene oxide 
• 100-51-6 benzyl alcohol 
• 103-82-2 phenylacetic acid 
• 599-67-7 1,1-diphenylethanol 
• 528-75-6 2,4-dinitrobenzaldehyde 
• 100-52-7 benzaldehyde 
• 104-94-9 4-methoxy-aniline 
• 504-63-2 trimethyleneglycol 
• 60-12-8 2-phenylethanol 
• 774-48-1 (diethoxymethyl)benzene 
• 583-60-8 2-Methylcyclohexanone 
• 65849-85-6 3,3,9,9-Tetramethyl-1,5,7,11-tetraoxaspiro<5.5>undecan 
• 62999-86-4 5,5-Dimethyl-2-N,N-dimethylamino-1,3-dioxane 

Downstream Products

• 100-52-7 benzaldehyde 
• 38216-93-2 3-benzyloxypivalic aldehyde 
• 36881-14-8 3-(benzyloxy)-2,2-dimethylpropionic acid 
• 65-85-0 benzoic acid 
• 50547-87-0 3-(benzoyloxy)-2,2-dimethylpropanoic acid 
• 5616-55-7 2-phenyl-1,3-dithiane 
• 581-55-5 benzylidene 1,1-diacetate 
• 70659-74-4 3-bromo-2,2-dimethylpropyl benzoate 
• 121353-10-4 (3R,5S,7S)-1-Benzyloxy-9-(tert-butyl-diphenyl-silanyloxy)-7-methoxymethoxy-2,2-dimethyl-nonane-3,5-diol 
• 121353-10-4 (3S,5S,7S)-1-Benzyloxy-9-(tert-butyl-diphenyl-silanyloxy)-7-methoxymethoxy-2,2-dimethyl-nonane-3,5-diol 
• 121352-88-3 [(2R,3R)-3-(2-Benzyloxy-1,1-dimethyl-ethyl)-oxiranyl]-methanol 
• 130199-57-4 ((2S,3S)-3-(1-(benzyloxy)-2-methylpropan-2-yl)oxiran-2-yl)methanol 
• 121353-16-0 (S)-7-[2-(tert-Butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-{(4S,6R)-6-[(S)-4-(tert-butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-5-hydroxy-2-methyl-dec-9-en-3-one 
• 121353-16-0 (R)-7-[2-(tert-Butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-{(4S,6R)-6-[(S)-4-(tert-butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-5-hydroxy-2-methyl-dec-9-en-3-one 

Relevant articles and documents

Evaluation of the Pharmacophoric Role of the O-O Bond in Synthetic Antileishmanial Compounds: Comparison between 1,2-Dioxanes and Tetrahydropyrans

Leishmaniases are neglected diseases that can be treated with a limited drug arsenal; the development of new molecules is therefore a priority. Recent evidence indicates that endoperoxides, including artemisinin and its derivatives, possess antileishmanial activity. Here, 1,2-dioxanes were synthesized with their corresponding tetrahydropyrans lacking the peroxide bridge, to ascertain if this group is a key pharmacophoric requirement for the antileishmanial bioactivity. Newly synthesized compounds were examined in vitro, and their mechanism of action was preliminarily investigated. Three endoperoxides and their corresponding tetrahydropyrans effectively inhibited the growth of Leishmania donovani promastigotes and amastigotes, and iron did not play a significant role in their activation. Further, reactive oxygen species were produced in both endoperoxide-and tetrahydropyran-Treated promastigotes. In conclusion, the peroxide group proved not to be crucial for the antileishmanial bioactivity of endoperoxides, under the tested conditions. Our findings reveal the potential of both 1,2-dioxanes and tetrahydropyrans as lead compounds for novel therapies against Leishmania.

Phosphorus promoted SO42-/TiO2 solid acid catalyst for acetalization reaction

A novel phosphorus modifed SO42-/TiO2 catalyst was synthesized by a facile coprecipitation method, followed by calcination. The catalytic performance of this novel solid acid was evaluated by acetalization. The results showed that the phosphorus was very effcient to enhance the catalytic activity of SO42-/TiO2. The solid acid owned high activity for the acetalization with the yields over 90%. Moreover, the solid acid could be reused for six times without loss of initial catalytic activities.

Four acid-catalysed dehydration reactions proceed without interference

Four acid-catalysed dehydration reactions can proceed in one pot, simultaneously and without interference, to yield one imine, one acetal (or boronic ester), one ester and one alkene, even though many other cross-products could be conceived. This advanced