tert-butyl (E)-3-(2-(benzyloxy)-6-(3-bromopropyl)-3-methoxyphenyl)acrylate

Base Information

Chemical Name:tert-butyl (E)-3-(2-(benzyloxy)-6-(3-bromopropyl)-3-methoxyphenyl)acrylate
CAS No.:1620754-30-4
Molecular Formula:C₂₄H₂₉BrO₄
Molecular Weight:461.396
Hs Code.:

Synonyms:tert-butyl (E)-3-(2-(benzyloxy)-6-(3-bromopropyl)-3-methoxyphenyl)acrylate

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Chemical Property of tert-butyl (E)-3-(2-(benzyloxy)-6-(3-bromopropyl)-3-methoxyphenyl)acrylate

Chemical Property:

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Technology Process of tert-butyl (E)-3-(2-(benzyloxy)-6-(3-bromopropyl)-3-methoxyphenyl)acrylate

There total 4 articles about tert-butyl (E)-3-(2-(benzyloxy)-6-(3-bromopropyl)-3-methoxyphenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 2-(benzyloxy)-1-iodo-3-methoxybenzene

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 109-64-8
1,3-dibromo-propane

: 1620754-30-4
tert-butyl (E)-3-(2-(benzyloxy)-6-(3-bromopropyl)-3-methoxyphenyl)acrylate

Guidance literature:: With norborn-2-ene; palladium diacetate; caesium carbonate; triphenylphosphine; In acetonitrile; at 90 ℃; for 16h; Inert atmosphere; Sealed tube;
DOI:10.1002/ejoc.201402218

Reference yield:

: 30778-85-9
2-Methoxy-1-(tetrahydro-2H-pyran-2-yloxy)-benzol

: 1620754-30-4
tert-butyl (E)-3-(2-(benzyloxy)-6-(3-bromopropyl)-3-methoxyphenyl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0 - 20 °C / Inert atmosphere

1.2: -78 - 20 °C

2.1: potassium carbonate / acetone / 2 h / Reflux

3.1: palladium diacetate; triphenylphosphine; caesium carbonate; norborn-2-ene / acetonitrile / 16 h / 90 °C / Inert atmosphere; Sealed tube

With norborn-2-ene; n-butyllithium; palladium diacetate; potassium carbonate; caesium carbonate; triphenylphosphine; In tetrahydrofuran; hexane; acetone; acetonitrile;
DOI:10.1002/ejoc.201402218

Reference yield:

: 90-05-1
2-methoxy-phenol

: 1620754-30-4
tert-butyl (E)-3-(2-(benzyloxy)-6-(3-bromopropyl)-3-methoxyphenyl)acrylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridinium p-toluenesulfonate / dichloromethane / 4 h / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.2: -78 - 20 °C

3.1: potassium carbonate / acetone / 2 h / Reflux

4.1: palladium diacetate; triphenylphosphine; caesium carbonate; norborn-2-ene / acetonitrile / 16 h / 90 °C / Inert atmosphere; Sealed tube

With norborn-2-ene; n-butyllithium; palladium diacetate; pyridinium p-toluenesulfonate; potassium carbonate; caesium carbonate; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; acetone; acetonitrile;
DOI:10.1002/ejoc.201402218