Desmethoxyacetyliopromid

Base Information

• Chemical Name: Desmethoxyacetyliopromid
• CAS No.: 154361-51-0
• Molecular Formula: C15H20 I3 N3 O6
• Molecular Weight: 719.054
• Hs Code.: 2924296000
• Mol file: 154361-51-0.mol

Synonyms:1,3-Benzenedicarboxamide,5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-N-methyl- (9CI)

Chemical Property of Desmethoxyacetyliopromid

Chemical Property:

• Boiling Point: 785.5±60.0 °C(Predicted)
• PKA: 11.97±0.46(Predicted)
• PSA: 156.35000
• Density: 2.316±0.06 g/cm3(Predicted)
• LogP: 0.56290

Purity/Quality:

98.5% ^*data from raw suppliers

N-DesmethoxyacetylIopromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Desmethoxyacetyl Iopromide is an impurity in the synthesis of Iopromide (I735700), a nonionic radiocontrast medium. Diagnostic aid (radiopaque medium).

Technology Process of Desmethoxyacetyliopromid

There total 5 articles about Desmethoxyacetyliopromid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

5-amino-N1,N3-bis(2,3-dihydroxypropyl)-N1-methylisophthalamide → 5-amino-N1,N3-bis(2,3-dihydroxypropyl)2,4,6-triiodo-N1-methylisophthalamide (154361-51-0)

Guidance literature:

With sulfuric acid; Iodine monochloride; potassium iodide; sodium chloride; In water; at 50 ℃; for 24h;

Reference yield:

methyl 3-((2,3-dihydroxypropyl)carbamoyl)-5-nitrobenzoate → 5-amino-N1,N3-bis(2,3-dihydroxypropyl)2,4,6-triiodo-N1-methylisophthalamide (154361-51-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 20 - 25 °C

2: palladium 10% on activated carbon; hydrogen / water / 7 h / 20 °C / 30003 - 33753.4 Torr

3: potassium iodide; sodium chloride; Iodine monochloride; sulfuric acid / water / 24 h / 50 °C

With sulfuric acid; palladium 10% on activated carbon; hydrogen; Iodine monochloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium iodide; sodium chloride; In water; N,N-dimethyl-formamide;

Reference yield:

5-nitro-1,3-benzenedicarboxylic acid, monomethyl ester (1955-46-0) → 5-amino-N1,N3-bis(2,3-dihydroxypropyl)2,4,6-triiodo-N1-methylisophthalamide (154361-51-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: dichloromethane; N,N-dimethyl-formamide / 0.17 h / 25 °C

1.2: 0.5 h

2.1: dichloromethane; ethanol / 0.5 h / -30 - 20 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 20 - 25 °C

4.1: palladium 10% on activated carbon; hydrogen / water / 7 h / 20 °C / 30003 - 33753.4 Torr

5.1: potassium iodide; sodium chloride; Iodine monochloride; sulfuric acid / water / 24 h / 50 °C

With sulfuric acid; palladium 10% on activated carbon; hydrogen; Iodine monochloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium iodide; sodium chloride; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

5-nitro-1,3-benzenedicarboxylic acid, monomethyl ester

methyl 5-nitro-3-chloroformylbenzoate

Downstream raw materials:

iopromide

Refernces

• 1、 -. "Preparation methods of iopromide and intermediate of iopromide". . . Retrieved 2018/03/24.