2-(4-Hydroxymethylphenyl)isonicotinic acid

Base Information

• Chemical Name: 2-(4-Hydroxymethylphenyl)isonicotinic acid
• CAS No.: 154352-41-7
• Molecular Formula: C14H13 N O3
• Molecular Weight: 243.262
• Mol file: 154352-41-7.mol

Synonyms:2-(4-Hydroxymethylphenyl)isonicotinic acid;2-(4-Hydroxymethylphenyl)nicotinic acid;2-(4-Hydroxymethylphenyl)nicotinic acid methyl ester;6-(4-Hydroxymethylphenyl)+B103pyridine-2-carboxylic acid

Chemical Property of 2-(4-Hydroxymethylphenyl)isonicotinic acid

Chemical Property:

• PSA: 70.42000
• LogP: 1.93910

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-Hydroxymethylphenyl)isonicotinic acid

There total 1 articles about 2-(4-Hydroxymethylphenyl)isonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromonicotinic acid methyl ester (52718-95-3) + bis(acetonitrile)palladium(II) dichloride + [(4-trimethylstannyl)phenyl]methanol (130677-18-8) → methyl 2-[(4-hydroxymethyl)phenyl]-3-pyridinecarboxylate (154352-41-7)

Guidance literature:

With CuI; bis(triphenylphosphine)palladium(II) dichloride; In water; N,N-dimethyl-formamide;

Reference yield:

methyl 2-[(4-hydroxymethyl)phenyl]-3-pyridinecarboxylate (154352-41-7) → methyl 2-[(4-chloromethyl)phenyl]-3-pyridinecarboxylate (154352-42-8)

Guidance literature:

With thionyl chloride; zinc(II) chloride; In 1,4-dioxane;

upstream raw materials:

2-bromonicotinic acid methyl ester

[(4-trimethylstannyl)phenyl]methanol

Downstream raw materials:

methyl 2-[(4-chloromethyl)phenyl]-3-pyridinecarboxylate

Refernces