52718-95-3

Basic information

• Product Name: 2-Bromo-3-pyridinecarboxylic acid methyl ester
• Synonyms: METHYL 2-BROMOPYRIDINE-3-CARBOXYLATE;2-BROMO-3-PYRIDINE-3-CARBOXYLIC ACID METHYL ESTER;2-BROMO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER;Methyl 2-bromopyridin-3-carboxylate;Methyl 2-broMo-3-pyridinecarboxylate;3-pyridinecarboxylic acid, 2-bromo-, methyl ester
• CAS NO: 52718-95-3
• Molecular Formula: C₇H₆BrNO₂
• Molecular Weight: 216.03
• EINECS: -0
• Mol File: 52718-95-3.mol
• Article Data: 16

Chemical Properties

• Melting Point: 32-37°C
• Boiling Point: 255.3 °C at 760 mmHg
• Flash Point: 108.2 °C
• Appearance: /
• Density: 1.58 g/cm³
• Vapor Pressure: 0.016mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -1.25±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-3-pyridinecarboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-3-pyridinecarboxylic acid methyl ester(52718-95-3)
• EPA Substance Registry System: 2-Bromo-3-pyridinecarboxylic acid methyl ester(52718-95-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 52718-95-3(Hazardous Substances Data)

Usage

General Description

2-Bromo-3-pyridinecarboxylic acid methyl ester is a chemical compound with the molecular formula C8H7BrNO2. It is an ester derivative of 2-bromo-3-pyridinecarboxylic acid and is commonly used in organic synthesis and pharmaceutical research. It is a white to off-white solid at room temperature and is soluble in a variety of organic solvents. 2-Bromo-3-pyridinecarboxylic acid methyl ester is often used as a building block in the synthesis of various pharmaceuticals and agrochemicals due to its reactivity and versatility. Additionally, it is important to handle this compound with care, as it is considered to be an irritant to the skin, eyes, and respiratory system.

InChI:InChI=1/C7H6BrNO2/c1-11-7(10)5-3-2-4-9-6(5)8/h2-4H,1H3

Upstream product

• 67-56-1 methanol 
• 35905-85-2 2-bromonicotinic acid 
• 100921-66-2 bromo-2 butyl-3 pyridine 
• 109-04-6 2-bromo-pyridine 
• 124-38-9 carbon dioxide 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 13070-22-9 3-(N,N-diethylamino)propenal 
• 105-34-0 methyl 2-cyanoacetate 
• 654084-12-5 2-bromonicotinoyl chloride 
• 128071-75-0 2-bromopyridine-3-carboxaldehyde 
• 1972-28-7 diethylazodicarboxylate 
• 3430-17-9 2-bromo-3-picoline 
• 186581-53-3 diazomethane 

Downstream Products

• 218138-60-4 4-(2-t-Butylaminosulfonyl-phenyl)-phenyl 2-(3-cyanophenyl)-pyridine-3-carboxamide 
• 53087-82-4 2-{4-[3-hydroxy-3-(4-hydroxy-phenyl)-2,2,4,4-tetramethyl-cyclobutyl]-piperazin-1-yl}-nicotinic acid methyl ester 
• 136483-17-5 methyl 2-trifluoromethyl-3-pyridinecarboxylate 
• 3882-46-0 5H-indeno[1,2-b]pyridin-5-one 
• 90903-73-4 2-Phenylamino-3-(1'-methyl-1'-hydroxy-ethyl)pyridin 
• 59361-45-4 methyl 2-((3-(trifluoromethyl)phenyl)amino)nicotinate 

Relevant articles and documents

1,3-bis(2-pyridyl)benzene receptor unit and indacenodipyridine diketone organic semiconductor material and application of organic semiconductor material

The invention discloses a 1,3-bis(2-pyridyl)benzene receptor unit and an indacenodipyridine diketone organic semiconductor material and application of the organic semiconductor material. 1,3-bis(2-pyridyl)benzene is taken as a basic skeleton, an electron

A ultrasonic process for synthesizing 2 - halogenated nicotinate and intermediates thereof

The invention discloses a method for synthesizing 2-halogenated ester nicotinate and a 2-halogenated ester nicotinate intermediate according to an ultrasonic method. The method comprises the following steps: adding substituent amino acrolein, a catalyst and cyanacetic ester into a reactor for a reaction under ultrasonic radiation; tracing the reaction till substituent amino acrolein is disappeared, thereby obtaining a reaction solution I containing the 2-halogenated ester nicotinate intermediate; then, adding halogen hydride into the reaction solution I for another reaction to obtain a reaction solution II; tracing and monitoring the reaction till completion; adding a lye into the reaction solution II to adjust the pH value of the reaction solution II to be 5-6; carrying out standing stratification to obtain a water layer and an organic layer; conducting extraction on the water layer by utilizing an organic solvent, and then combining the extraction solution with the organic layer; carrying out refining to obtain 2-halogenated ester nicotinate. Through the adoption of the method, an organic synthesis reaction can be effectively facilitated, the reaction speed and yield can be improved, and the environmental protection can be promoted; the reaction time is short and the operation is simple, that is, the organic synthesis reaction can be finished within 2 hours in general; the product yield and quality are high; specifically, the product yield can reach 90% or higher, and exceed that achieved according to the conventional solvent heating reflux method.

HEMOGLOBIN MODIFIER COMPOUNDS AND USES THEREOF

Described herein are compounds, including pharmaceutically acceptable salts thereof, methods of making such compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat, prevent or diagnose blood-based diseases, disorders or conditions.