ethyl 4-[N-methyl-N-(5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-yl)amino]benzoate

Base Information

Chemical Name:ethyl 4-[N-methyl-N-(5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-yl)amino]benzoate
CAS No.:311348-55-7
Molecular Formula:C₂₄H₃₁NO₂
Molecular Weight:365.516
Hs Code.:

Synonyms:ethyl 4-[N-methyl-N-(5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-yl)amino]benzoate

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Chemical Property of ethyl 4-[N-methyl-N-(5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-yl)amino]benzoate

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Technology Process of ethyl 4-[N-methyl-N-(5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-yl)amino]benzoate

There total 3 articles about ethyl 4-[N-methyl-N-(5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-yl)amino]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 214694-10-7
4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-ylamino)-benzoic acid ethyl ester

: 74-88-4
methyl iodide

: 311348-55-7
ethyl 4-[N-methyl-N-(5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-yl)amino]benzoate

Guidance literature:: 4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-ylamino)-benzoic acid ethyl ester; With sodium hydride; In N,N-dimethyl-formamide; for 0.333333h;

methyl iodide; In N,N-dimethyl-formamide; for 0.5h;
DOI:10.1248/cpb.48.1504

Reference yield:

: 51934-41-9
4-iodobenzoic acid ethyl ester

: 311348-55-7
ethyl 4-[N-methyl-N-(5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-yl)amino]benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 48 percent / Pd(dba)3; (R)-BINAP; tert-BuONa / toluene / 1 h / 80 °C

2.1: NaH / dimethylformamide / 0.33 h

2.2: 100 percent / dimethylformamide / 0.5 h

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; sodium t-butanolate; In N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.48.1504

Reference yield:

: 92050-16-3
5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylamine

: 311348-55-7
ethyl 4-[N-methyl-N-(5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-yl)amino]benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 48 percent / Pd(dba)3; (R)-BINAP; tert-BuONa / toluene / 1 h / 80 °C

2.1: NaH / dimethylformamide / 0.33 h

2.2: 100 percent / dimethylformamide / 0.5 h

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; sodium t-butanolate; In N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.48.1504