(2S,2'S)-dimethyl 2,2'-(((2R,2'R)-3,3'-diselanediylbis(2-((tert butoxycarbonyl)amino)propanoyl))bis(azanediyl))bis(3-phenylpropanoate)

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Chemical Name:(2S,2'S)-dimethyl 2,2'-(((2R,2'R)-3,3'-diselanediylbis(2-((tert butoxycarbonyl)amino)propanoyl))bis(azanediyl))bis(3-phenylpropanoate)
CAS No.:1415256-74-4
Molecular Formula:C₃₆H₅₀N₄O₁₀Se₂
Molecular Weight:856.734
Hs Code.:

Synonyms:(2S,2'S)-dimethyl 2,2'-(((2R,2'R)-3,3'-diselanediylbis(2-((tert butoxycarbonyl)amino)propanoyl))bis(azanediyl))bis(3-phenylpropanoate)

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Chemical Property of (2S,2'S)-dimethyl 2,2'-(((2R,2'R)-3,3'-diselanediylbis(2-((tert butoxycarbonyl)amino)propanoyl))bis(azanediyl))bis(3-phenylpropanoate)

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Technology Process of (2S,2'S)-dimethyl 2,2'-(((2R,2'R)-3,3'-diselanediylbis(2-((tert butoxycarbonyl)amino)propanoyl))bis(azanediyl))bis(3-phenylpropanoate)

There total 4 articles about (2S,2'S)-dimethyl 2,2'-(((2R,2'R)-3,3'-diselanediylbis(2-((tert butoxycarbonyl)amino)propanoyl))bis(azanediyl))bis(3-phenylpropanoate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1415256-80-2
(S)-methyl 2-((R)-2-((tert-butoxycarbonyl)amino)-3-((4-methylbenzoyl)selanyl)propanamido)-3-phenylpropanoate

: 1415256-74-4
(2S,2'S)-dimethyl 2,2'-(((2R,2'R)-3,3'-diselanediylbis(2-((tert butoxycarbonyl)amino)propanoyl))bis(azanediyl))bis(3-phenylpropanoate)

Guidance literature:: With piperazine; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tet.2012.08.082

Reference yield:

: 1415256-40-4
(S)-tert-butyl 2-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)carbamoyl)aziridine-1-carboxylate

: 1415256-74-4
(2S,2'S)-dimethyl 2,2'-(((2R,2'R)-3,3'-diselanediylbis(2-((tert butoxycarbonyl)amino)propanoyl))bis(azanediyl))bis(3-phenylpropanoate)

Guidance literature:: Multi-step reaction with 2 steps

1: indium iodide / dichloromethane / 7 h / 20 °C / Inert atmosphere

2: piperazine / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

With piperazine; indium iodide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.08.082

Reference yield:

: 1415256-83-5
methyl ((S)-1-tritylaziridine-2-carbonyl)-L-phenylalaninate

: 1415256-74-4
(2S,2'S)-dimethyl 2,2'-(((2R,2'R)-3,3'-diselanediylbis(2-((tert butoxycarbonyl)amino)propanoyl))bis(azanediyl))bis(3-phenylpropanoate)

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid; methanol / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

1.2: 0.17 h / 0 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 15 h / 0 - 20 °C / Inert atmosphere

3.1: indium iodide / dichloromethane / 7 h / 20 °C / Inert atmosphere

4.1: piperazine / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

With piperazine; methanol; indium iodide; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.08.082