tert-butyl [2-(1-cyclohexyl-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]carbamate

Base Information

Chemical Name:tert-butyl [2-(1-cyclohexyl-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]carbamate
CAS No.:1085538-55-1
Molecular Formula:C₂₂H₃₂N₂O₃
Molecular Weight:372.508
Hs Code.:

Synonyms:tert-butyl [2-(1-cyclohexyl-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]carbamate

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Chemical Property of tert-butyl [2-(1-cyclohexyl-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]carbamate

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Technology Process of tert-butyl [2-(1-cyclohexyl-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]carbamate

There total 1 articles about tert-butyl [2-(1-cyclohexyl-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 4530-20-5
BOC-glycine

: 1085538-51-7
1-cyclohexyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 1085538-55-1
tert-butyl [2-(1-cyclohexyl-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]carbamate

Guidance literature:: BOC-glycine; With 4-methyl-morpholine; pivaloyl chloride; In dichloromethane; at 5 - 20 ℃; for 0.5h;

1-cyclohexyl-1,2,3,4-tetrahydroisoquinoline hydrochloride; In dichloromethane; at 4 - 20 ℃; for 14h;
DOI:10.1016/j.bmc.2014.10.020

Reference yield: 99.0%

: 1085538-55-1
tert-butyl [2-(1-cyclohexyl-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]carbamate

: 1085538-57-3
2-(1-cyclohexyl-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethanamine

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 5 - 50 ℃; for 5h;
DOI:10.1016/j.bmc.2014.10.020

Reference yield:

: 1085538-55-1
tert-butyl [2-(1-cyclohexyl-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]carbamate

: 1-(1-cyclohexyl-3,4-dihydroisoquinolin-2(1H)-yl)-2-{[(1-hydroxycycloheptyl)methyl]amino}ethanone oxalate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / ethyl acetate / 5 h / 5 - 50 °C

2.1: isopropyl alcohol / 15 h / Reflux

2.2: 60 °C

With hydrogenchloride; In ethyl acetate; isopropyl alcohol;
DOI:10.1016/j.bmc.2014.10.020