Technology Process of (S)-2-(2-hydroxyphenyl)-4,5-dihydrothiazole-4-carbaldehyde
There total 3 articles about (S)-2-(2-hydroxyphenyl)-4,5-dihydrothiazole-4-carbaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(4S)-2-(2-hydroxyphenyl)-4,5-dihydrothiazole-4-carboxylic acid N-methoxy-N-methylamide;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at -40 - -30 ℃;
for 0.5h;
Inert atmosphere;
With
ammonium chloride;
In
tetrahydrofuran; water;
DOI:10.1021/ol1028173
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate / 12 h / 60 °C / pH 6.4 / Inert atmosphere; aq. phosphate buffer
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere
3: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -40 - -30 °C / Inert atmosphere
With
lithium aluminium tetrahydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ol1028173
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere
2: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -40 - -30 °C / Inert atmosphere
With
lithium aluminium tetrahydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ol1028173
