androst-5-ene-3β,17α-diyl 3-acetate 17-benzoate

Base Information

• Chemical Name: androst-5-ene-3β,17α-diyl 3-acetate 17-benzoate
• CAS No.: 40768-03-4
• Molecular Formula: C₂₈H₃₆O₄
• Molecular Weight: 436.591
• Mol file: 40768-03-4.mol

Synonyms:androst-5-ene-3β,17α-diyl 3-acetate 17-benzoate

Chemical Property of androst-5-ene-3β,17α-diyl 3-acetate 17-benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of androst-5-ene-3β,17α-diyl 3-acetate 17-benzoate

There total 5 articles about androst-5-ene-3β,17α-diyl 3-acetate 17-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

17α-hydroxyandrost-5-en-3β-yl 3-acetate (100428-85-1) + benzoyl chloride (98-88-4) → androst-5-ene-3β,17α-diyl 3-acetate 17-benzoate (40768-03-4)

Guidance literature:

With pyridine; for 20h; Ambient temperature;

DOI:10.1135/cccc19930600

Reference yield:

prasterone acetate (853-23-6) → androst-5-ene-3β,17α-diyl 3-acetate 17-benzoate (40768-03-4) + 3β-acetoxy-17β-benzoyloxy-androst-5-ene (5953-63-9)

Guidance literature:

With ethanol; nickel; Hydrogenation_.Behandlung des Reaktionsprodukts mit Benzoylchlorid und Pyridin; Trennung der Stereoisomeren durch fraktionierte Krystallisation aus Isopropylalkohol;

DOI:10.1002/hlca.193601901115 DOI:10.1002/hlca.193501801176 DOI:10.1002/hlca.193501801201

Reference yield:

5-androstene-3β,17β-diol 3-acetate 17-p-toluene-δ-sulfonate (1259-22-9) → androst-5-ene-3β,17α-diyl 3-acetate 17-benzoate (40768-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 44 percent / NaNO₂ / dimethylsulfoxide / 1 h / 135 °C

2: 64 percent / pyridine / 20 h / Ambient temperature

With pyridine; sodium nitrite; In dimethyl sulfoxide;

DOI:10.1135/cccc19930600

upstream raw materials:

prasterone acetate

17α-hydroxyandrost-5-en-3β-yl 3-acetate

benzoyl chloride

5-androstene-3β,17β-diol 3-acetate 17-p-toluene-δ-sulfonate

Downstream raw materials:

3β-acetoxy-17α-benzoyloxyandrost-5-en-7-one

androst-5-ene-3β,17α-diyl diacetate

androstanedione

Androstenedione