Technology Process of (2R,3S)-2-methoxy-3-methyl-4-(phenylmethoxy)butanal
There total 5 articles about (2R,3S)-2-methoxy-3-methyl-4-(phenylmethoxy)butanal which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(3S,4S)-3-methoxy-4-methyl-5-(phenylmethoxy)-1-pentene;
With
ozone;
In
dichloromethane;
at -78 ℃;
for 1h;
With
dimethylsulfide;
In
dichloromethane;
at -30 - 18 ℃;
for 0.5h;
DOI:10.3987/COM-12-12597
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: trifluorormethanesulfonic acid / cyclohexane; dichloromethane / 16 h / 0 - 22 °C / Inert atmosphere
2.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -15 °C / Inert atmosphere
3.1: vinyl magnesium bromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
4.1: zinc borohydride / dichloromethane; diethyl ether / 2.5 h / -78 - 0 °C / Inert atmosphere
5.1: potassium hydride / tetrahydrofuran; mineral oil / 0.25 h / 18 °C / Inert atmosphere
5.2: 0.25 h / 0 - 18 °C / Inert atmosphere
6.1: ozone / dichloromethane / 1 h / -78 °C
6.2: 0.5 h / -30 - 18 °C
With
trifluorormethanesulfonic acid; zinc borohydride; vinyl magnesium bromide; isopropylmagnesium chloride; potassium hydride; ozone;
In
tetrahydrofuran; diethyl ether; dichloromethane; cyclohexane; mineral oil;
DOI:10.3987/COM-12-12597
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: vinyl magnesium bromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
2.1: zinc borohydride / dichloromethane; diethyl ether / 2.5 h / -78 - 0 °C / Inert atmosphere
3.1: potassium hydride / tetrahydrofuran; mineral oil / 0.25 h / 18 °C / Inert atmosphere
3.2: 0.25 h / 0 - 18 °C / Inert atmosphere
4.1: ozone / dichloromethane / 1 h / -78 °C
4.2: 0.5 h / -30 - 18 °C
With
zinc borohydride; vinyl magnesium bromide; potassium hydride; ozone;
In
tetrahydrofuran; diethyl ether; dichloromethane; mineral oil;
DOI:10.3987/COM-12-12597
