Technology Process of (3S,4S)-3-methoxy-4-methyl-5-(phenylmethoxy)-1-pentene
There total 4 articles about (3S,4S)-3-methoxy-4-methyl-5-(phenylmethoxy)-1-pentene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(3S,4S)-4-methyl-5-(phenylmethoxy)-1-penten-3-ol;
With
potassium hydride;
In
tetrahydrofuran; mineral oil;
at 18 ℃;
for 0.25h;
Inert atmosphere;
methyl iodide;
In
tetrahydrofuran; mineral oil;
at 0 - 18 ℃;
for 0.25h;
Inert atmosphere;
DOI:10.3987/COM-12-12597
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: trifluorormethanesulfonic acid / cyclohexane; dichloromethane / 16 h / 0 - 22 °C / Inert atmosphere
2.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -15 °C / Inert atmosphere
3.1: vinyl magnesium bromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
4.1: zinc borohydride / dichloromethane; diethyl ether / 2.5 h / -78 - 0 °C / Inert atmosphere
5.1: potassium hydride / tetrahydrofuran; mineral oil / 0.25 h / 18 °C / Inert atmosphere
5.2: 0.25 h / 0 - 18 °C / Inert atmosphere
With
trifluorormethanesulfonic acid; zinc borohydride; vinyl magnesium bromide; isopropylmagnesium chloride; potassium hydride;
In
tetrahydrofuran; diethyl ether; dichloromethane; cyclohexane; mineral oil;
DOI:10.3987/COM-12-12597
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: vinyl magnesium bromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
2.1: zinc borohydride / dichloromethane; diethyl ether / 2.5 h / -78 - 0 °C / Inert atmosphere
3.1: potassium hydride / tetrahydrofuran; mineral oil / 0.25 h / 18 °C / Inert atmosphere
3.2: 0.25 h / 0 - 18 °C / Inert atmosphere
With
zinc borohydride; vinyl magnesium bromide; potassium hydride;
In
tetrahydrofuran; diethyl ether; dichloromethane; mineral oil;
DOI:10.3987/COM-12-12597
