(2R,3S,4R)-1-allyl-3,4-bis(benzyloxy)-2-((R)-1-(benzyloxy)allyl)-pyrrolidine

Base Information

Chemical Name:(2R,3S,4R)-1-allyl-3,4-bis(benzyloxy)-2-((R)-1-(benzyloxy)allyl)-pyrrolidine
CAS No.:1579996-93-2
Molecular Formula:C₃₁H₃₅NO₃
Molecular Weight:469.624
Hs Code.:

Synonyms:(2R,3S,4R)-1-allyl-3,4-bis(benzyloxy)-2-((R)-1-(benzyloxy)allyl)-pyrrolidine

Suppliers and Price of (2R,3S,4R)-1-allyl-3,4-bis(benzyloxy)-2-((R)-1-(benzyloxy)allyl)-pyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3S,4R)-1-allyl-3,4-bis(benzyloxy)-2-((R)-1-(benzyloxy)allyl)-pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3S,4R)-1-allyl-3,4-bis(benzyloxy)-2-((R)-1-(benzyloxy)allyl)-pyrrolidine

There total 16 articles about (2R,3S,4R)-1-allyl-3,4-bis(benzyloxy)-2-((R)-1-(benzyloxy)allyl)-pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₃₁NO₃

: 106-95-6
allyl bromide

: 1579996-93-2
(2R,3S,4R)-1-allyl-3,4-bis(benzyloxy)-2-((R)-1-(benzyloxy)allyl)-pyrrolidine

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1039/c3ra47555g

Reference yield:

: (4R,5S,6R)-4,5-bis(benzyloxy)-6-(trityloxymethyl)tetrahydro-2H-pyran-2,3-diol

: 1579996-93-2
(2R,3S,4R)-1-allyl-3,4-bis(benzyloxy)-2-((R)-1-(benzyloxy)allyl)-pyrrolidine

Guidance literature:: Multi-step reaction with 15 steps

1.1: sodium periodate; sodium hydrogencarbonate / water; ethanol / 4 h / 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate / methanol / 1.08 h / 0 - 20 °C / Inert atmosphere

3.1: triethylamine; dmap / dichloromethane / 0 °C / Inert atmosphere

4.1: 18-crown-6 ether / N,N-dimethyl-formamide / 8 h / 120 °C / Inert atmosphere

5.1: sodium / methanol / 0.5 h / 0 - 20 °C / Inert atmosphere

6.1: triethylamine; dmap / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

6.2: 0.17 h / Inert atmosphere

7.1: 2 h / 70 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere

9.1: hydrogen; 10 wt% Pd(OH)2 on carbon / methanol / 1 h / 20 °C / 760.05 Torr / Inert atmosphere

10.1: sodium carbonate / ethyl acetate / 2 h / 20 °C / Inert atmosphere

11.1: chromium(VI) oxide; acetic anhydride; pyridine / dichloromethane / 1.25 h / 0 - 20 °C / Inert atmosphere

12.1: potassium tert-butylate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

13.1: trifluorormethanesulfonic acid / dichloromethane; cyclohexane; hexane / 2 h / 20 °C / Inert atmosphere

14.1: trifluoroacetic acid / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere

15.1: sodium hydride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

With pyridine; chromium(VI) oxide; dmap; sodium tetrahydroborate; sodium periodate; 18-crown-6 ether; trifluorormethanesulfonic acid; 10 wt% Pd(OH)2 on carbon; potassium tert-butylate; hydrogen; sodium; acetic anhydride; sodium hydride; sodium hydrogencarbonate; sodium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; cyclohexane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1039/c3ra47555g

Reference yield:

: 1579996-59-0
(2R,3S,4R)-2,3-bis(benzyloxy)-5-(trityloxy)pentane-1,4-diol

: 1579996-93-2
(2R,3S,4R)-1-allyl-3,4-bis(benzyloxy)-2-((R)-1-(benzyloxy)allyl)-pyrrolidine

Guidance literature:: Multi-step reaction with 13 steps

1.1: triethylamine; dmap / dichloromethane / 0 °C / Inert atmosphere

2.1: 18-crown-6 ether / N,N-dimethyl-formamide / 8 h / 120 °C / Inert atmosphere

3.1: sodium / methanol / 0.5 h / 0 - 20 °C / Inert atmosphere

4.1: triethylamine; dmap / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

4.2: 0.17 h / Inert atmosphere

5.1: 2 h / 70 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere

7.1: hydrogen; 10 wt% Pd(OH)2 on carbon / methanol / 1 h / 20 °C / 760.05 Torr / Inert atmosphere

8.1: sodium carbonate / ethyl acetate / 2 h / 20 °C / Inert atmosphere

9.1: chromium(VI) oxide; acetic anhydride; pyridine / dichloromethane / 1.25 h / 0 - 20 °C / Inert atmosphere

10.1: potassium tert-butylate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

11.1: trifluorormethanesulfonic acid / dichloromethane; cyclohexane; hexane / 2 h / 20 °C / Inert atmosphere

12.1: trifluoroacetic acid / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere

13.1: sodium hydride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

With pyridine; chromium(VI) oxide; dmap; 18-crown-6 ether; trifluorormethanesulfonic acid; 10 wt% Pd(OH)2 on carbon; potassium tert-butylate; hydrogen; sodium; acetic anhydride; sodium hydride; sodium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; cyclohexane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1039/c3ra47555g