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tert-butyl (5S)-6-chloro-5-hydroxy-3-oxohexanoate

Base Information Edit
  • Chemical Name:tert-butyl (5S)-6-chloro-5-hydroxy-3-oxohexanoate
  • CAS No.:154026-92-3
  • Molecular Formula:C10H17ClO4
  • Molecular Weight:236.696
  • Hs Code.:2918990090
  • DSSTox Substance ID:DTXSID40427414
  • Nikkaji Number:J1.476.616B
  • Wikidata:Q82240068
  • Mol file:154026-92-3.mol
tert-butyl (5S)-6-chloro-5-hydroxy-3-oxohexanoate

Synonyms:154026-92-3;tert-butyl (5S)-6-chloro-5-hydroxy-3-oxohexanoate;tert-Butyl (S)-6-chloro-5-hydroxy-3-oxohexanoate;tert-Butyl 6-Chloro-5(S)-hydroxy-3-oxohexanoate;(S)-tert-Butyl 6-chloro-5-hydroxy-3-oxohexanoate;SCHEMBL1135909;(s)-6-chloro-5-hydroxy-3-oxo-hexanoic acid t-butylester;DTXSID40427414;WLRFCPQXWBDLRG-QMMMGPOBSA-N;CS-0165317;EN300-9443250;t-butyl (s)-6-chloro-5-hydroxy-3-ketohexanoate;(S)-tert-Butyl6-chloro-5-hydroxy-3-oxohexanoate;tert-butyl(5S)-6-chloro-5-hydroxy-3-oxohexanoate;(S)-3-Oxo-5-hydroxy-6-chlorohexanoic acid tert-butyl ester;(5S)-6-Chloro-5-hydroxy-3-oxo-hexanoic Acid 1,1-Dimethylethyl Ester.;(S)-tert-butyl 6-chloro-5-hydroxy-3-oxohexanoate? (Rosuvastatin Impurity pound(c);(S)-6-Chloro-5-hydroxy-3-oxo-hexanoic Acid 1,1-Dimethylethyl Ester;(5S)-6-Chloro-5-hydroxy-3-oxohexanoic acid tert-butyl ester

Suppliers and Price of tert-butyl (5S)-6-chloro-5-hydroxy-3-oxohexanoate
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • tert-Butyl6-Chloro-5(S)-hydroxy-3-oxohexanoate
  • 50mg
  • $ 180.00
  • TRC
  • tert-Butyl6-Chloro-5(S)-hydroxy-3-oxohexanoate
  • 500mg
  • $ 1390.00
  • Crysdot
  • (S)-tert-Butyl6-chloro-5-hydroxy-3-oxohexanoate 97%
  • 1g
  • $ 1032.00
  • Chemenu
  • tert-butyl(5S)-6-chloro-5-hydroxy-3-oxohexanoate 95%+
  • 20mg
  • $ 315.00
  • American Custom Chemicals Corporation
  • TERT-BUTYL (S)-6-CHLORO-5-HYDROXY-3-OXOHEXANOATE 95.00%
  • 1G
  • $ 1210.32
Total 33 raw suppliers
Chemical Property of tert-butyl (5S)-6-chloro-5-hydroxy-3-oxohexanoate Edit
Chemical Property:
  • PSA:63.60000 
  • LogP:1.27710 
  • Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere 
  • Solubility.:Chloroform (Slightly), Methanol (Slightly) 
  • XLogP3:0.9
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:4
  • Rotatable Bond Count:7
  • Exact Mass:236.0815367
  • Heavy Atom Count:15
  • Complexity:232
Purity/Quality:

98% *data from raw suppliers

tert-Butyl6-Chloro-5(S)-hydroxy-3-oxohexanoate *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC(C)(C)OC(=O)CC(=O)CC(CCl)O
  • Isomeric SMILES:CC(C)(C)OC(=O)CC(=O)C[C@@H](CCl)O
  • Uses tert-Butyl 6-Chloro-5(S)-hydroxy-3-oxohexanoate used in the synthesis of statins or HMG-CoA reductase inhibitors.
Technology Process of tert-butyl (5S)-6-chloro-5-hydroxy-3-oxohexanoate

There total 9 articles about tert-butyl (5S)-6-chloro-5-hydroxy-3-oxohexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
bromoacetic acid tert-butyl ester; (3S)-4-chloro-3-[(trimethylsilyl)oxy]butyronitrile; With zinc; In tetrahydrofuran; at 63 - 65 ℃; for 2h; Inert atmosphere;
With hydrogenchloride; water; In tetrahydrofuran; at 0 ℃; for 1h;
Guidance literature:
With methanesulfonic acid; zinc; In tetrahydrofuran; Heating / reflux;
2-bromo-2-tert-butyl acetic acid; (3S)-4-chloro-3-[(trimethylsilyl)oxy]butyronitrile; In tetrahydrofuran; for 1.5h; Heating / reflux;
With hydrogenchloride; In tetrahydrofuran; water; for 3h; pH=4;
Guidance literature:
acetic acid tert-butyl ester; ethyl (S)-4-chloro-3-hydroxybutanoate; With tert-butyl magnesium (1+); chloride; In tetrahydrofuran; toluene; at 0 - 5 ℃; for 1h;
With lithium diisopropyl amide; In tetrahydrofuran; hexane; toluene; at 5 ℃; for 19h;
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