50364-40-4Relevant articles and documents
Preparation method of 3,3-dimethyl-2-oxobutyric acid
-
Paragraph 0035; 0036, (2018/10/04)
The invention relates to a preparation method of 3,3-dimethyl-2-oxobutyric acid, and belongs to the technical field of pharmaceutical intermediate synthesis. In order to solve the problems of seriouspollution and low yield of the existing synthetic route, the invention provides a preparation method of 3,3-dimethyl-2-oxobutyric acid, and the method comprises: halogenating 3,3-dimethyl butyric acidwith a halogenating agent in an organic solvent to obtain an intermediate product; then carrying out a hydrolysis reaction to obtain a corresponding hydrolyzed product; and in the presence of TEMPO catalyst, oxidizing the hydrolyzed product under the action of an oxidant, and then carrying out acidification to obtain a product 3,3-dimethyl-2-oxobutyric acid. According to the preparation method provided by the invention, a mixed catalyst of a noble metal catalyst and a transition metal catalyst is avoided, the environmental pollution and the cost are reduced, and the effects of high yield andhigh purity can still be ensured.
Derecemization par protonation enantioselective. Application aux composes carbonyles α-asymetriques
Duhamel, Lucette,Plaquevent, Jean-Christophe
, p. 69 - 74 (2007/10/02)
Derecemization by enantioselective protonation, a new method for the optical enrichment of a racemic mixture, is described and compared to classical methods.This work describes the deracemization of α-asymmetric carbonyl compounds.They are converted into their enamines, which after protonation by a chiral acid and hydrolysis lead to optically active carbonyl compounds.A mechanism responsible for the optical activation is suggested by means of a study of the reaction conditions and parameters modifying the selectivity.A rule for the determination of the absolute configuration of carbonyl compounds is proposed in view of the results.