5-o-Tolyl-[1,3,4]thiadiazole-2-carboximidic acid ethyl ester; hydrochloride

Base Information

Chemical Name:5-o-Tolyl-[1,3,4]thiadiazole-2-carboximidic acid ethyl ester; hydrochloride
CAS No.:110718-57-5
Molecular Formula:C₁₂H₁₃N₃OS*ClH
Molecular Weight:283.782
Hs Code.:

Synonyms:5-o-Tolyl-[1,3,4]thiadiazole-2-carboximidic acid ethyl ester; hydrochloride

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Chemical Property of 5-o-Tolyl-[1,3,4]thiadiazole-2-carboximidic acid ethyl ester; hydrochloride

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Technology Process of 5-o-Tolyl-[1,3,4]thiadiazole-2-carboximidic acid ethyl ester; hydrochloride

There total 4 articles about 5-o-Tolyl-[1,3,4]thiadiazole-2-carboximidic acid ethyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 64-17-5
ethanol

: 110718-51-9
2-cyano-5-(2-methylphenyl)-1,3,4-thiadiazole

: 110718-57-5
5-o-Tolyl-[1,3,4]thiadiazole-2-carboximidic acid ethyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; at 0 - 10 ℃; for 0.5h;
DOI:10.1021/jm00396a004

Reference yield:

: 110718-49-5
2-(chloromethyl)-5-(2-methylphenyl)-1,3,4-thiadiazole

: 110718-57-5
5-o-Tolyl-[1,3,4]thiadiazole-2-carboximidic acid ethyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 45 percent / HCl gas, isoamyl nitrite / dioxane / 1.5 h / < 50 deg C

2: 91 percent / NaN₃ / dimethylformamide / 6 h / Ambient temperature

3: 60 percent / glacial AcOH / 72 h / Ambient temperature

4: 64 percent / HCl gas / diethyl ether / 0.5 h / 0 - 10 °C

With hydrogenchloride; sodium azide; acetic acid; isopentyl nitrite; In 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm00396a004

Reference yield:

: 110825-31-5
5-(2-methylphenyl)-1,3,4-thiadiazole-2-hydroxamic acid chloride

: 110718-57-5
5-o-Tolyl-[1,3,4]thiadiazole-2-carboximidic acid ethyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / NaN₃ / dimethylformamide / 6 h / Ambient temperature

2: 60 percent / glacial AcOH / 72 h / Ambient temperature

3: 64 percent / HCl gas / diethyl ether / 0.5 h / 0 - 10 °C

With hydrogenchloride; sodium azide; acetic acid; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm00396a004