Technology Process of methyl 2-diazo-4-phenylheptanoate
There total 7 articles about methyl 2-diazo-4-phenylheptanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
p-nitrobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
dichloromethane;
at 0 - 20 ℃;
for 1h;
Yield given;
DOI:10.1021/ja9515213
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 2.77 g / NaH, CH3OH / 1,2-dimethoxy-ethane / 13 h / Heating
2: DBU, 4-nitrobenzenesulfonyl azide / CH2Cl2 / 1 h / 0 - 20 °C
With
methanol; p-nitrobenzenesulfonyl azide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/ja9515213
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 6.04 g / pyridine / CH2Cl2 / 12 h / Ambient temperature
2: 4.74 g / tetrahydrofuran / 13 h / 0 - 20 °C
3: 1.) O3, 2.) PH3P, 3.) NaHCO3, Br2
4: 2.77 g / NaH, CH3OH / 1,2-dimethoxy-ethane / 13 h / Heating
5: DBU, 4-nitrobenzenesulfonyl azide / CH2Cl2 / 1 h / 0 - 20 °C
With
pyridine; methanol; p-nitrobenzenesulfonyl azide; bromine; sodium hydride; sodium hydrogencarbonate; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/ja9515213
