3-(4-(2-(bis(9,9-dimethyl-9H-fluoren-7-yl)amino)-9,9-spirobifluoren-7-yl)phenyl)-2-cyanoacrylic acid

Base Information

Chemical Name:3-(4-(2-(bis(9,9-dimethyl-9H-fluoren-7-yl)amino)-9,9-spirobifluoren-7-yl)phenyl)-2-cyanoacrylic acid
CAS No.:1185882-68-1
Molecular Formula:C₆₅H₄₆N₂O₂
Molecular Weight:887.092
Hs Code.:

Synonyms:3-(4-(2-(bis(9,9-dimethyl-9H-fluoren-7-yl)amino)-9,9-spirobifluoren-7-yl)phenyl)-2-cyanoacrylic acid

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Chemical Property of 3-(4-(2-(bis(9,9-dimethyl-9H-fluoren-7-yl)amino)-9,9-spirobifluoren-7-yl)phenyl)-2-cyanoacrylic acid

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Technology Process of 3-(4-(2-(bis(9,9-dimethyl-9H-fluoren-7-yl)amino)-9,9-spirobifluoren-7-yl)phenyl)-2-cyanoacrylic acid

There total 7 articles about 3-(4-(2-(bis(9,9-dimethyl-9H-fluoren-7-yl)amino)-9,9-spirobifluoren-7-yl)phenyl)-2-cyanoacrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1185882-64-7
4-(2-(bis(9,9-dimethyl-9H-fluoren-7-yl)amino)-9,9-spirobifluoren-7-yl)benzaldehyde

: 372-09-8
cyanoacetic acid

: 1185882-68-1
3-(4-(2-(bis(9,9-dimethyl-9H-fluoren-7-yl)amino)-9,9-spirobifluoren-7-yl)phenyl)-2-cyanoacrylic acid

Guidance literature:: With piperidine; In chloroform; for 10h; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2009.05.028

Reference yield: 55.0%

: 110-89-4
piperidine

aqueous hydrogen chloride: aqueous hydrogen chloride

: 372-09-8
cyanoacetic acid

: 1185882-68-1
3-(4-(2-(bis(9,9-dimethyl-9H-fluoren-7-yl)amino)-9,9-spirobifluoren-7-yl)phenyl)-2-cyanoacrylic acid

Guidance literature:: In chloroform; magnesium sulfate;

Reference yield:

: 171408-84-7
2,7-dibromo-9,9'-spirobi[fluorene]

: 1185882-68-1
3-(4-(2-(bis(9,9-dimethyl-9H-fluoren-7-yl)amino)-9,9-spirobifluoren-7-yl)phenyl)-2-cyanoacrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 8 h / 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran; water / Inert atmosphere; Reflux

3.1: tri-tert-butyl phosphine; palladium diacetate; caesium carbonate / toluene / 130 °C / Inert atmosphere

4.1: piperidine / chloroform / 10 h / Inert atmosphere; Reflux

With piperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; tri-tert-butyl phosphine; palladium diacetate; potassium carbonate; caesium carbonate; In tetrahydrofuran; hexane; chloroform; water; toluene; 2.1: Suzuki coupling;
DOI:10.1016/j.tet.2009.05.028