ethyl 2-(2,6-dichloro-5-fluoropyridine-3-carbonyl)-3-(dimethylamino)prop-2-enoate

Base Information

Chemical Name:ethyl 2-(2,6-dichloro-5-fluoropyridine-3-carbonyl)-3-(dimethylamino)prop-2-enoate
CAS No.:132112-09-5
Molecular Formula:C₁₃H₁₃Cl₂FN₂O₃
Molecular Weight:335.162
Hs Code.:

Synonyms:ethyl 2-(2,6-dichloro-5-fluoropyridine-3-carbonyl)-3-(dimethylamino)prop-2-enoate

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Chemical Property of ethyl 2-(2,6-dichloro-5-fluoropyridine-3-carbonyl)-3-(dimethylamino)prop-2-enoate

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Technology Process of ethyl 2-(2,6-dichloro-5-fluoropyridine-3-carbonyl)-3-(dimethylamino)prop-2-enoate

There total 2 articles about ethyl 2-(2,6-dichloro-5-fluoropyridine-3-carbonyl)-3-(dimethylamino)prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 924-99-2,1117-37-9,114894-59-6
ethyl 3-(dimethylamino)acrylate

: 82671-06-5
2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid

: 132112-09-5
ethyl 2-(2,6-dichloro-5-fluoropyridine-3-carbonyl)-3-(dimethylamino)prop-2-enoate

Guidance literature:: 2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid; With thionyl chloride; at 80 ℃; for 2h;

ethyl 3-(dimethylamino)acrylate; With N-ethyl-N,N-diisopropylamine; In toluene; at 20 - 90 ℃; for 3.75h;

Reference yield:

: 82671-06-5
2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid

: 132112-09-5
ethyl 2-(2,6-dichloro-5-fluoropyridine-3-carbonyl)-3-(dimethylamino)prop-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 2 h / 80 °C

2: N-ethyl-N,N-diisopropylamine / toluene / 90 °C

With thionyl chloride; N-ethyl-N,N-diisopropylamine; In toluene;

Reference yield:

: 132112-09-5
ethyl 2-(2,6-dichloro-5-fluoropyridine-3-carbonyl)-3-(dimethylamino)prop-2-enoate

: C₂₁H₁₈ClFN₂O₅

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 20 °C

2: potassium carbonate / toluene / 110 °C

With potassium carbonate; In toluene;
DOI:10.3184/030823410X12890461346708