(R)-ε-oxo-β-<2-(triphenylphosphoranyl)ethyl>benzenehexanoic acid bromide

Base Information

Chemical Name:(R)-ε-oxo-β-<2-(triphenylphosphoranyl)ethyl>benzenehexanoic acid bromide
CAS No.:142437-97-6
Molecular Formula:Br*C₃₂H₃₂O₃P
Molecular Weight:575.482
Hs Code.:

Synonyms:(R)-ε-oxo-β-<2-(triphenylphosphoranyl)ethyl>benzenehexanoic acid bromide

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Chemical Property of (R)-ε-oxo-β-<2-(triphenylphosphoranyl)ethyl>benzenehexanoic acid bromide

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Technology Process of (R)-ε-oxo-β-<2-(triphenylphosphoranyl)ethyl>benzenehexanoic acid bromide

There total 5 articles about (R)-ε-oxo-β-<2-(triphenylphosphoranyl)ethyl>benzenehexanoic acid bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-3-(2-Hydroxy-ethyl)-5-(2-phenyl-[1,3]dioxolan-2-yl)-pentanoic acid ethyl ester

: 142437-97-6
(R)-ε-oxo-β-<2-(triphenylphosphoranyl)ethyl>benzenehexanoic acid bromide

Guidance literature:: Multi-step reaction with 3 steps

1: 1M aq. HCl / tetrahydrofuran

2: tetrahydrofuran; H₂O / 0.25 h / Heating

3: 11.7 g / dimethylsulfoxide / 2 h / 160 °C

With hydrogenchloride; In tetrahydrofuran; water; dimethyl sulfoxide;
DOI:10.1021/jo00043a038

Reference yield:

: 142437-94-3
diethyl 3-<2-(2-phenyl-1,3-dioxan-2-yl)ethyl>pentanedioate

: 142437-97-6
(R)-ε-oxo-β-<2-(triphenylphosphoranyl)ethyl>benzenehexanoic acid bromide

Guidance literature:: Multi-step reaction with 5 steps

1: porcine liver esterase (PLE, EC 3.3.1.1), phosphate puffer, 3.2M (NH₄)2SO₄, 1M NaOH / 72 h / Ambient temperature; pH 7-7.2

2: BH₃ / tetrahydrofuran / 2.5 h

3: 1M aq. HCl / tetrahydrofuran

4: tetrahydrofuran; H₂O / 0.25 h / Heating

5: 11.7 g / dimethylsulfoxide / 2 h / 160 °C

With hydrogenchloride; ammonium sulfate; sodium hydroxide; phosphate puffer; porcine liver esterase (PLE, EC 3.3.1.1); borane; In tetrahydrofuran; water; dimethyl sulfoxide;
DOI:10.1021/jo00043a038

Reference yield:

: 142437-92-1,142437-93-2
(E)-5-(2-Phenyl-[1,3]dioxolan-2-yl)-pent-2-enoic acid ethyl ester

: 142437-97-6
(R)-ε-oxo-β-<2-(triphenylphosphoranyl)ethyl>benzenehexanoic acid bromide

Guidance literature:: Multi-step reaction with 6 steps

1: 69 percent / Al(iso-but)3, TfOH / CH₂Cl₂; toluene / -78 deg C to r. t., 1 h

2: porcine liver esterase (PLE, EC 3.3.1.1), phosphate puffer, 3.2M (NH₄)2SO₄, 1M NaOH / 72 h / Ambient temperature; pH 7-7.2

3: BH₃ / tetrahydrofuran / 2.5 h

4: 1M aq. HCl / tetrahydrofuran

5: tetrahydrofuran; H₂O / 0.25 h / Heating

6: 11.7 g / dimethylsulfoxide / 2 h / 160 °C

With hydrogenchloride; ammonium sulfate; sodium hydroxide; trifluorormethanesulfonic acid; phosphate puffer; porcine liver esterase (PLE, EC 3.3.1.1); borane; triisobutylaluminum; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; toluene;
DOI:10.1021/jo00043a038