(S)-3-[4-[(5-iodo-4-pentenoyl)amino]phenoxy]-1-(isopropylamino)propan-2-ol

Base Information

• Chemical Name: (S)-3-[4-[(5-iodo-4-pentenoyl)amino]phenoxy]-1-(isopropylamino)propan-2-ol
• CAS No.: 256937-63-0
• Molecular Formula: C₁₇H₂₅IN₂O₃
• Molecular Weight: 432.302

Synonyms:(S)-3-[4-[(5-iodo-4-pentenoyl)amino]phenoxy]-1-(isopropylamino)propan-2-ol

Chemical Property of (S)-3-[4-[(5-iodo-4-pentenoyl)amino]phenoxy]-1-(isopropylamino)propan-2-ol

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Technology Process of (S)-3-[4-[(5-iodo-4-pentenoyl)amino]phenoxy]-1-(isopropylamino)propan-2-ol

There total 1 articles about (S)-3-[4-[(5-iodo-4-pentenoyl)amino]phenoxy]-1-(isopropylamino)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-3-[4-[(5-tributylstannyl-4-pentenoyl)amino]phenoxy]-1-(isopropylamino)propan-2-ol → (S)-3-[4-[(5-iodo-4-pentenoyl)amino]phenoxy]-1-(isopropylamino)propan-2-ol (256937-63-0)

Guidance literature:

With Iodine monochloride; In dichloromethane; at 20 ℃;

DOI:10.1002/(SICI)1099-1344(199912)42:12<1195::AID-JLCR275>3.0.CO;2-R

Reference yield: 88.0%

benzyl bromide (100-39-0) + (S)-3-[4-[(5-iodo-4-pentenoyl)amino]phenoxy]-1-(isopropylamino)propan-2-ol (256937-63-0) → (S)-3-[4-[(5-iodo-4-pentenoyl)amino]phenoxy]-1-(N-benzylisopropylamino)propan-2-ol

Guidance literature:

With potassium carbonate; In acetonitrile; for 2h; Heating;

DOI:10.1002/(SICI)1099-1344(199912)42:12<1195::AID-JLCR275>3.0.CO;2-R

Reference yield:

(S)-3-[4-[(5-iodo-4-pentenoyl)amino]phenoxy]-1-(isopropylamino)propan-2-ol (256937-63-0) → (S)-3-[4-[(5-iodo-4-pentenoyl)amino]phenoxy]-1-(N-benzylisopropylamino)prop-2-yl (R)-2-fluoro-2-phenylacetate

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / K₂CO₃ / acetonitrile / 2 h / Heating

2: pyridine / CH₂Cl₂ / 20 °C

With pyridine; potassium carbonate; In dichloromethane; acetonitrile; 1: Alkylation / 2: Esterification;

DOI:10.1002/(SICI)1099-1344(199912)42:12<1195::AID-JLCR275>3.0.CO;2-R

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