16E-veratrylidenestrone

Base Information

• Chemical Name: 16E-veratrylidenestrone
• CAS No.: 1585174-06-6
• Molecular Formula: C₂₇H₃₀O₄
• Molecular Weight: 418.533
• Mol file: 1585174-06-6.mol

Synonyms:16E-veratrylidenestrone

Chemical Property of 16E-veratrylidenestrone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 16E-veratrylidenestrone

There total 1 articles about 16E-veratrylidenestrone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

Estrone (53-16-7) + 3,4-dimethoxy-benzaldehyde (120-14-9) → 16E-veratrylidenestrone (1585174-06-6)

Guidance literature:

With potassium hydroxide; In ethanol; for 5h; Reflux;

DOI:10.1016/j.steroids.2014.01.003

Reference yield: 85.0%

16E-veratrylidenestrone (1585174-06-6) + indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) + (RS)-4-thiazolidinecarboxylic acid (444-27-9,19291-02-2,34592-47-7,45521-09-3,2756-91-4,6070-92-4,60731-25-1) → spiro[5'.3]oxindolespiro[6'.16]-7'-(3,4-dimethoxyphenyl)tetrahydro-1H-pyrrolo[1',2'-c][1',3']thiazoloestrone (1585173-63-2)

Guidance literature:

In isopropyl alcohol; for 3h; stereoselective reaction; Reflux;

DOI:10.1016/j.steroids.2014.01.003

Reference yield: 80.0%

16E-veratrylidenestrone (1585174-06-6) + (RS)-4-thiazolidinecarboxylic acid (444-27-9,19291-02-2,34592-47-7,45521-09-3,2756-91-4,6070-92-4,60731-25-1) + acenaphthene quinone (82-86-0) → spiro[5'.2]acenaphthylene-1-onespiro[16.6']-7'-(3,4-dimethoxyphenyl)tetrahydro-1H-pyrrolo[1',2'-c][1',3']thiazoloestrone (1585173-95-0)

Guidance literature:

In isopropyl alcohol; for 3h; stereoselective reaction; Reflux;

DOI:10.1016/j.steroids.2014.01.003

upstream raw materials:

Estrone

3,4-dimethoxy-benzaldehyde

Downstream raw materials:

spiro[5'.3]oxindolespiro[6'.16]-7'-(3,4-dimethoxyphenyl)tetrahydro-1H-pyrrolo[1',2'-c][1',3']thiazoloestrone

spiro[5'.2]acenaphthylene-1-onespiro[16.6']-7'-(3,4-dimethoxyphenyl)tetrahydro-1H-pyrrolo[1',2'-c][1',3']thiazoloestrone