(R)-1-((R)-1-benzylpiperazin-2-yl)ethan-1-ol

Base Information

Chemical Name:(R)-1-((R)-1-benzylpiperazin-2-yl)ethan-1-ol
CAS No.:249611-13-0
Molecular Formula:C₁₃H₂₀N₂O
Molecular Weight:220.315
Hs Code.:
DSSTox Substance ID:DTXSID701210495

Synonyms:(R)-1-((R)-1-benzylpiperazin-2-yl)ethan-1-ol;249611-13-0;(1R)-1-[(2R)-1-benzylpiperazin-2-yl]ethanol;DTXSID701210495;MFCD30470709;AKOS030529240;AS-41192;(R)-1-((R)-1-Benzylpiperazin-2-yl)ethanol

Suppliers and Price of (R)-1-((R)-1-benzylpiperazin-2-yl)ethan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-((R)-1-benzylpiperazin-2-yl)ethan-1-ol

Chemical Property:

XLogP3:0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:220.157563266
Heavy Atom Count:16
Complexity:204

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C1CNCCN1CC2=CC=CC=C2)O
Isomeric SMILES:C[C@H]([C@H]1CNCCN1CC2=CC=CC=C2)O

Technology Process of (R)-1-((R)-1-benzylpiperazin-2-yl)ethan-1-ol

There total 5 articles about (R)-1-((R)-1-benzylpiperazin-2-yl)ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 249611-05-0
(1R,3R,8aS)-(-)-1-Methyl-3-phenyl-1,6,7,8a-tetrahydro[1,3]oxazolo[3,4-a]pyrazine-5,8-dione

: 249611-13-0
(1R)-(-)-1-[(2R)-1-Benzylpiperazin-2-yl]ethan-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; for 72h; Heating;
DOI:10.1055/s-1999-3596

Reference yield:

: 100-52-7
benzaldehyde

: 249611-13-0
(1R)-(-)-1-[(2R)-1-Benzylpiperazin-2-yl]ethan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: Et₃N; MgSO₄ / methanol / 24 h / 20 °C

1.2: 55 percent / Et₃N / CH₂Cl₂ / 17 h / -5 - 20 °C

2.1: 94 percent / NaN₃ / dimethylsulfoxide / 24 h / 60 °C

3.1: 96 percent / H₂ / 10 percent Pd/C / methanol / 16 h / 20 °C

4.1: 76 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 72 h / Heating

With lithium aluminium tetrahydride; sodium azide; hydrogen; magnesium sulfate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dimethyl sulfoxide; 1.1: Cycloaddition / 1.2: Acylation / 2.1: Substitution / 3.1: Cyclization / 4.1: Reduction;
DOI:10.1055/s-1999-3596

Reference yield:

: 249610-98-8
(2R,4S,5R)-(+)-Methyl 3-(2-chloroacetyl)-5-methyl-2-phenyl-1,3-oxazolidine-4-carboxylate

: 249611-13-0
(1R)-(-)-1-[(2R)-1-Benzylpiperazin-2-yl]ethan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / NaN₃ / dimethylsulfoxide / 24 h / 60 °C

2: 96 percent / H₂ / 10 percent Pd/C / methanol / 16 h / 20 °C

3: 76 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 72 h / Heating

With lithium aluminium tetrahydride; sodium azide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dimethyl sulfoxide; 1: Substitution / 2: Cyclization / 3: Reduction;
DOI:10.1055/s-1999-3596