5-Chloro-4-(2-chloro-4'-fluoro-5-(pyridazin-4-yl)biphenyl-4-yloxy)-N-(2,4-dimethoxybenzyl)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

Base Information

Chemical Name:5-Chloro-4-(2-chloro-4'-fluoro-5-(pyridazin-4-yl)biphenyl-4-yloxy)-N-(2,4-dimethoxybenzyl)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide
CAS No.:1354787-08-8
Molecular Formula:C₃₃H₂₃Cl₂F₂N₅O₅S₂
Molecular Weight:742.611
Hs Code.:

Synonyms:5-Chloro-4-(2-chloro-4'-fluoro-5-(pyridazin-4-yl)biphenyl-4-yloxy)-N-(2,4-dimethoxybenzyl)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

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Chemical Property of 5-Chloro-4-(2-chloro-4'-fluoro-5-(pyridazin-4-yl)biphenyl-4-yloxy)-N-(2,4-dimethoxybenzyl)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

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Technology Process of 5-Chloro-4-(2-chloro-4'-fluoro-5-(pyridazin-4-yl)biphenyl-4-yloxy)-N-(2,4-dimethoxybenzyl)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

There total 7 articles about 5-Chloro-4-(2-chloro-4'-fluoro-5-(pyridazin-4-yl)biphenyl-4-yloxy)-N-(2,4-dimethoxybenzyl)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1354787-09-9
2-Chloro-4'-fluoro-5-(pyridazin-4-yl)biphenyl-4-ol

: 1235406-57-1
5-chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

: 1354787-08-8
5-Chloro-4-(2-chloro-4'-fluoro-5-(pyridazin-4-yl)biphenyl-4-yloxy)-N-(2,4-dimethoxybenzyl)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 18h;

Reference yield:

: 13631-21-5
4-bromo-3-chlorophenol

: 1354787-08-8
5-Chloro-4-(2-chloro-4'-fluoro-5-(pyridazin-4-yl)biphenyl-4-yloxy)-N-(2,4-dimethoxybenzyl)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 80 °C / Inert atmosphere

2: sulfuric acid; acetic acid; N-iodo-succinimide / dichloromethane / 2 h / 20 °C

3: cesium fluoride; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 2 h / 50 °C / Inert atmosphere

4: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C

With N-iodo-succinimide; copper(l) iodide; sulfuric acid; potassium carbonate; caesium carbonate; acetic acid; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; acetonitrile; 1: Suzuki Coupling / 3: Stille Coupling;

Reference yield:

: 1765-93-1
4-fluoroboronic acid

: 1354787-08-8
5-Chloro-4-(2-chloro-4'-fluoro-5-(pyridazin-4-yl)biphenyl-4-yloxy)-N-(2,4-dimethoxybenzyl)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 80 °C / Inert atmosphere

2: sulfuric acid; acetic acid; N-iodo-succinimide / dichloromethane / 2 h / 20 °C

3: cesium fluoride; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 2 h / 50 °C / Inert atmosphere

4: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C

With N-iodo-succinimide; copper(l) iodide; sulfuric acid; potassium carbonate; caesium carbonate; acetic acid; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; acetonitrile; 1: Suzuki Coupling / 3: Stille Coupling;