13631-21-5

Usage

Uses

Used in Organic Synthesis:
4-BROMO-3-CHLOROPHENOL is used as a precursor in organic synthesis for the preparation of various compounds. One such example is the synthesis of 4-(benzyloxy)-l-bromo-2-chlorobenzene, which is achieved by reacting 4-BROMO-3-CHLOROPHENOL with benzyl bromide. This reaction demonstrates the utility of 4-BROMO-3-CHLOROPHENOL in creating complex organic molecules for further applications in different industries.

InChI:InChI=1/C6H4BrClO/c7-5-2-1-4(9)3-6(5)8/h1-3,9H

Upstream product

• 108-43-0 3-monochlorophenol 
• 29682-39-1 1-bromo-2-chloro-4-nitrobenzene 
• 554-84-7 meta-nitrophenol 
• 40140-91-8 3-chloro-4-nitrosophenol 
• 21402-26-6 4-bromo-3-chloroaniline 

Downstream Products

• 50638-46-5 4-bromo-3-chloroanisole 
• 40979-03-1 2,4,6-tribromo-3-chlorophenol 
• 65001-78-7 4-bromo-5-chloro-2-nitrophenol 
• 23719-22-4 2-Chloro-4-bisphenylol 
• 550998-16-8 3-chloro-4-(6-methoxy-2-naphthyl)phenol 
• 729590-57-2 1-((4-bromo-3-chlorophenoxy)methyl)benzene 
• 1079042-87-7 C₁₃H₆BrClN₂O₃ 
• 1316808-79-3 C₉H₁₂BrClOSi 
• 1354786-31-4 5-Chloro-4-{[2-chloro-4'-fluoro-5-(pyridazin-4-yl)biphenyl-4-yl]oxy}-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide 
• 1354787-08-8 5-Chloro-4-(2-chloro-4'-fluoro-5-(pyridazin-4-yl)biphenyl-4-yloxy)-N-(2,4-dimethoxybenzyl)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide 
• 1354786-35-8 5-Chloro-4-{[2-chloro-3'-fluoro-5-(pyridazin-4-yl)biphenyl-4-yl]oxy}-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide 
• 1354787-05-5 5-Chloro-4-(2-chloro-3'-fluoro-5-(pyridazin-4-yl)biphenyl-4-yloxy)-N-(2,4-dimethoxybenzyl)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide 
• 1354786-36-9 5-Chloro-4-{[2-chloro-2'-fluoro-5-(pyridazin-4-yl)biphenyl-4-yl]oxy}-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide 
• 1354786-53-0 5-chloro-4-(2-chloro-2'-fluoro-5-(pyridazin-4-yl)biphenyl-4-yloxy)-N-(2,4-dimethoxybenzyl)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide 

Relevant academic research and scientific papers

Regioselective monobromination of phenols with KBr and ZnAl–BrO3?–layered double hydroxides

The regioselective mono-bromination of phenols has been successfully developed with KBr and ZnAl–BrO3?–layered double hydroxides (abbreviated as ZnAl–BrO3?–LDHs) as brominating reagents. The para site is much favorable and the ortho site takes the priority if para site is occupied. This reaction featured with excellent regioselectivity, cheap brominating reagents, mild reaction condition, high atom economy, broad substrate scope, and provided an efficient method to synthesize bromophenols.

Regioselective monobromination of substituted phenols in the presence of β-cyclodextrin

Cyclodextrin acts as a restricting nanovessel to enhance regioselectivity in bromination of substituted phenols such as 3-nitrophenol, 2-chlorophenol, 3-chlorophenol, and 4-chlorophenol. In contrast to solution bromination, cyclodextrin facilitates regioselective monobromination and formation of polybrominated products are substantially reduced. Selectivities in brominations are also observed in water and in the solid state. The observed results are rationalized on the basis of specific modes of inclusion of substituted phenols inside the cyclodextrin cavity and find strong support from energy minimization studies and 1H-1H NOESY.