(E)-3-(3-hydroxy-4-methoxyphenyl)-N-(1-methyl-1H-benzimidazol-2-yl)prop-2-enamide hydrochloride

Base Information

Chemical Name:(E)-3-(3-hydroxy-4-methoxyphenyl)-N-(1-methyl-1H-benzimidazol-2-yl)prop-2-enamide hydrochloride
CAS No.:1223568-49-7
Molecular Formula:C₁₈H₁₇N₃O₃*ClH
Molecular Weight:359.812
Hs Code.:

Synonyms:(E)-3-(3-hydroxy-4-methoxyphenyl)-N-(1-methyl-1H-benzimidazol-2-yl)prop-2-enamide hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-3-(3-hydroxy-4-methoxyphenyl)-N-(1-methyl-1H-benzimidazol-2-yl)prop-2-enamide hydrochloride

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Technology Process of (E)-3-(3-hydroxy-4-methoxyphenyl)-N-(1-methyl-1H-benzimidazol-2-yl)prop-2-enamide hydrochloride

There total 4 articles about (E)-3-(3-hydroxy-4-methoxyphenyl)-N-(1-methyl-1H-benzimidazol-2-yl)prop-2-enamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1223569-56-9
(E)-3-(3-acetoxy-4-methoxyphenyl)-N-(1-methyl-1H-benzimidazol-2-yl)prop-2-enamide

: 1223568-49-7
(E)-3-(3-hydroxy-4-methoxyphenyl)-N-(1-methyl-1H-benzimidazol-2-yl)prop-2-enamide hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; at 20 ℃; for 2h;
DOI:10.1021/jm500547c

Reference yield:

: 1234345-57-3
3-acetoxy-4-methoxycinnamoyl chloride

: 1223568-49-7
(E)-3-(3-hydroxy-4-methoxyphenyl)-N-(1-methyl-1H-benzimidazol-2-yl)prop-2-enamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 16 h / 5 - 20 °C

2: hydrogenchloride / methanol / 2 h / 20 °C

With hydrogenchloride; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1021/jm500547c

Reference yield:

: 134841-10-4
(2E)-3-[(3-acetyloxy)-4-methoxyphenyl]acrylic acid

: 1223568-49-7
(E)-3-(3-hydroxy-4-methoxyphenyl)-N-(1-methyl-1H-benzimidazol-2-yl)prop-2-enamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / tetrahydrofuran; N,N-dimethyl-formamide / 4 h / Reflux

2: triethylamine / tetrahydrofuran / 16 h / 5 - 20 °C

3: hydrogenchloride / methanol / 2 h / 20 °C

With hydrogenchloride; thionyl chloride; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm500547c