134841-10-4

Upstream product

• 141-82-2 malonic acid 
• 881-57-2 isovanillin acetate 
• 537-73-5 isoferulic acid 
• 108-24-7 acetic anhydride 
• 537-73-5 trans-3-hydroxy-4-methoxycinnamic acid 
• 75-36-5 acetyl chloride 

Downstream Products

• 537-73-5 trans-3-hydroxy-4-methoxycinnamic acid 
• 1613391-25-5 (E)-N-(3-chlorophenyl)-3-(3-hydroxy-4-methoxyphenyl)-N-methyl-prop-2-enamide 
• 1613391-41-5 (E)-N-(3-chlorophenyl)-3-(3-acetoxy-4-methoxyphenyl)-N-methyl-prop-2-enamide 
• 1223568-49-7 (E)-3-(3-hydroxy-4-methoxyphenyl)-N-(1-methyl-1H-benzimidazol-2-yl)prop-2-enamide hydrochloride 
• 1223569-56-9 (E)-3-(3-acetoxy-4-methoxyphenyl)-N-(1-methyl-1H-benzimidazol-2-yl)prop-2-enamide 
• 1223568-51-1 (E)-N-(1,3-benzoxazol-4-yl)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enamide 
• 1223568-17-9 (E)-3-(3-hydroxy-4-methoxyphenyl)-N-(1-naphthyl)prop-2-enamide 
• 1223569-25-2 (E)-3-(3-acetoxy-4-methoxyphenyl)-N-(1-naphthyl)prop-2-enamide 
• 1613391-39-1 (E)-3-(3-acetoxy-4-methoxyphenyl)-N-(2-naphthyl)-prop-2-enamide 

Relevant academic research and scientific papers

Synthesis and biological evaluation of curcuminoid derivatives

Many curcuminoid derivatives have been reported to have multiple biological activities. The aim of this study was to improve the biological activity of curcuminoids by synthesizing 16 new derivatives which combined cinnamic acids with curcuminoids, and we also analyzed the structure-activity relationship of the new compounds. Almost all the new compounds showed encouraging activity, especially compound 7g. It had much better antioxidant activity than curcuminoids and Vitamin C (VC), and also had the most significant antibacterial activity, which was 5-folder better than ampicillin (one of the best marketed antibiotics) with a minimum inhibitory concentration (MIC) of 0.5 μg/mL against Gram-positive cocci (Staphylococcus aureus and Streptococcus viridans) as well as Escherichia coli and 0.6 μg/mL against Enterobacter cloacae. Compound 7g also showed the greatest anticancer activity with a much lower IC50, which was 0.51 μM against MCF-7, 0.58 μM against HepG-2, 0.63 μM against LX-2, and 0.79 μM against 3T3. The results suggest that these compounds have promising potential as candidates for the treatment of cancer and thus further studies are warranted.

Composition of multiple isoflavone derivatives, preparing method and medical application

The invention discloses a composition of multiple isoflavone derivatives, and further discloses a preparing method of the composition and medical application of the composition in treating diabetes. The composition of the isoflavone derivatives is prepare

NEW GUANIDINE DERIVATIVES IN CINNAMIC SERIES

The invention relates to novel guanidine derivatives in the cinnamic series of general formula (I): The invention also relates to the process for preparing said guanidine derivatives and also to synthetic intermediates. Finally, the invention relates to t

Acrylamido derivatives useful as inhibitors of the mitochondrial permeability transition

Acrylamido derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of the mitochondrial permeability transition pore (MPTP), such as the diseases characterized by ischemia/reperfusion, oxidative or degenerative tissue damage, are herein described. These compounds belong to the structural formula (I) wherein R, R', R , W and a are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to pharmaceutical compositions comprising them.