(+/-)-ethyl 4-(3-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-6-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Base Information

Chemical Name:(+/-)-ethyl 4-(3-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-6-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS No.:1425492-74-5
Molecular Formula:C₂₅H₂₄N₂O₅S
Molecular Weight:464.542
Hs Code.:

Synonyms:(+/-)-ethyl 4-(3-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-6-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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Chemical Property of (+/-)-ethyl 4-(3-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-6-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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Technology Process of (+/-)-ethyl 4-(3-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-6-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

There total 4 articles about (+/-)-ethyl 4-(3-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-6-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1290078-26-0
3-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromene-6-carbaldehyde

: 141-97-9
ethyl acetoacetate

: 17356-08-0
thiourea

: 1425492-74-5
(+/-)-ethyl 4-(3-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-6-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: With toluene-4-sulfonic acid; In acetonitrile; Reflux;
DOI:10.1016/j.ejmech.2012.11.044

Reference yield:

: 104-01-8
4-Methoxyphenylacetic acid

: 1425492-74-5
(+/-)-ethyl 4-(3-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-6-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,3,5-trichloro-2,4,6-triazine; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 0.75 h / Reflux

2.1: toluene-4-sulfonic acid / acetonitrile / Reflux

With 4-methyl-morpholine; 1,3,5-trichloro-2,4,6-triazine; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; acetonitrile; 2.1: |Biginelli Pyrimidone Synthesis;
DOI:10.1016/j.ejmech.2012.11.044

Reference yield:

: 95-48-7,77504-84-8
ortho-cresol

: 1425492-74-5
(+/-)-ethyl 4-(3-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-6-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / 6 h / 120 °C

1.2: 4 h / 20 - 100 °C

2.1: 1,3,5-trichloro-2,4,6-triazine; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 0.75 h / Reflux

3.1: toluene-4-sulfonic acid / acetonitrile / Reflux

With 4-methyl-morpholine; 1,3,5-trichloro-2,4,6-triazine; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; acetonitrile; trifluoroacetic acid; 1.1: |Duff Aldehyde Synthesis / 1.2: |Duff Aldehyde Synthesis / 3.1: |Biginelli Pyrimidone Synthesis;
DOI:10.1016/j.ejmech.2012.11.044