(4R,5S)-3-[3-(2,4-difluoro-phenyl)-propionyl]-4-methyl-5-phenyl-oxazolidin-2-one

Base Information

Chemical Name:(4R,5S)-3-[3-(2,4-difluoro-phenyl)-propionyl]-4-methyl-5-phenyl-oxazolidin-2-one
CAS No.:849488-10-4
Molecular Formula:C₁₉H₁₇F₂NO₃
Molecular Weight:345.346
Hs Code.:

Synonyms:(4R,5S)-3-[3-(2,4-difluoro-phenyl)-propionyl]-4-methyl-5-phenyl-oxazolidin-2-one

Suppliers and Price of (4R,5S)-3-[3-(2,4-difluoro-phenyl)-propionyl]-4-methyl-5-phenyl-oxazolidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,5S)-3-[3-(2,4-difluoro-phenyl)-propionyl]-4-methyl-5-phenyl-oxazolidin-2-one

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Technology Process of (4R,5S)-3-[3-(2,4-difluoro-phenyl)-propionyl]-4-methyl-5-phenyl-oxazolidin-2-one

There total 1 articles about (4R,5S)-3-[3-(2,4-difluoro-phenyl)-propionyl]-4-methyl-5-phenyl-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 16251-45-9,17097-67-5,28044-22-6,28044-23-7,39663-75-7,54418-69-8,77943-39-6,125133-96-2,149055-02-7
(4S,5R)-4-methyl-5-phenyl-oxazolidin-2-one

: 134672-70-1
3-(2,4-difluorophenyl)-propionic acid

: 849488-10-4
(4R,5S)-3-[3-(2,4-difluoro-phenyl)-propionyl]-4-methyl-5-phenyl-oxazolidin-2-one

Guidance literature:: 3-(2,4-difluorophenyl)-propionic acid; With pivaloyl chloride; triethylamine; In tetrahydrofuran; at 0 ℃; for 1h;

(4S,5R)-4-methyl-5-phenyl-oxazolidin-2-one; With lithium chloride; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 849488-10-4
(4R,5S)-3-[3-(2,4-difluoro-phenyl)-propionyl]-4-methyl-5-phenyl-oxazolidin-2-one

: 425-75-2
trifluoromethanesulfonic acid ethyl ester

: 849488-11-5
(4R,5S)-[(S)-2-(2,4-difluoro-benzyl)-butyryl]-4-methyl-5-phenyl-oxazolidin-2-one

Guidance literature:: (4R,5S)-3-[3-(2,4-difluoro-phenyl)-propionyl]-4-methyl-5-phenyl-oxazolidin-2-one; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

trifluoromethanesulfonic acid ethyl ester; In tetrahydrofuran; at -70 - -30 ℃; for 1.5h;