5-cyclopentyl-1-(3-(4-fluorophenyl)-N-methylacrylamido)pent-3-yn-2-yl pivalate

Base Information

Chemical Name:5-cyclopentyl-1-(3-(4-fluorophenyl)-N-methylacrylamido)pent-3-yn-2-yl pivalate
CAS No.:1449377-89-2
Molecular Formula:C₂₅H₃₂FNO₃
Molecular Weight:413.532
Hs Code.:

Synonyms:5-cyclopentyl-1-(3-(4-fluorophenyl)-N-methylacrylamido)pent-3-yn-2-yl pivalate

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Chemical Property of 5-cyclopentyl-1-(3-(4-fluorophenyl)-N-methylacrylamido)pent-3-yn-2-yl pivalate

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Technology Process of 5-cyclopentyl-1-(3-(4-fluorophenyl)-N-methylacrylamido)pent-3-yn-2-yl pivalate

There total 4 articles about 5-cyclopentyl-1-(3-(4-fluorophenyl)-N-methylacrylamido)pent-3-yn-2-yl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13565-08-7
(E)-3-(4-fluorophenyl)acryloyl chloride

: 1449377-89-2
5-cyclopentyl-1-(3-(4-fluorophenyl)-N-methylacrylamido)pent-3-yn-2-yl pivalate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 - 20 °C

2.1: pyridinium p-toluenesulfonate / acetone; water / 48 h / Reflux

3.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 6 h / -78 - 0 °C

4.1: triethylamine; dmap / dichloromethane / 2 h

With dmap; n-butyllithium; pyridinium p-toluenesulfonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; acetone;
DOI:10.1002/anie.201207287

Reference yield:

: 1449378-07-7
3-(4-fluorophenyl)-N-methyl-N-(2-oxoethyl)acrylamide

: 1449377-89-2
5-cyclopentyl-1-(3-(4-fluorophenyl)-N-methylacrylamido)pent-3-yn-2-yl pivalate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 6 h / -78 - 0 °C

2.1: triethylamine; dmap / dichloromethane / 2 h

With dmap; n-butyllithium; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.201207287

Reference yield:

: C₁₄H₁₈FNO₃

: 1449377-89-2
5-cyclopentyl-1-(3-(4-fluorophenyl)-N-methylacrylamido)pent-3-yn-2-yl pivalate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridinium p-toluenesulfonate / acetone; water / 48 h / Reflux

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 6 h / -78 - 0 °C

3.1: triethylamine; dmap / dichloromethane / 2 h

With dmap; n-butyllithium; pyridinium p-toluenesulfonate; triethylamine; In tetrahydrofuran; dichloromethane; water; acetone;
DOI:10.1002/anie.201207287