2-(3-(2H-tetrazol-5-yl)propoxy)-5-chloro-N-(2-oxo-5-(2,4,6-trichlorophenyl)-2,3-dihydro-1-benzo[e][1,4]diazepin-3-yl)benzamide

Base Information

Chemical Name:2-(3-(2H-tetrazol-5-yl)propoxy)-5-chloro-N-(2-oxo-5-(2,4,6-trichlorophenyl)-2,3-dihydro-1-benzo[e][1,4]diazepin-3-yl)benzamide
CAS No.:1351763-65-9
Molecular Formula:C₂₆H₁₉Cl₄N₇O₃
Molecular Weight:619.294
Hs Code.:

Synonyms:2-(3-(2H-tetrazol-5-yl)propoxy)-5-chloro-N-(2-oxo-5-(2,4,6-trichlorophenyl)-2,3-dihydro-1-benzo[e][1,4]diazepin-3-yl)benzamide

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Chemical Property of 2-(3-(2H-tetrazol-5-yl)propoxy)-5-chloro-N-(2-oxo-5-(2,4,6-trichlorophenyl)-2,3-dihydro-1-benzo[e][1,4]diazepin-3-yl)benzamide

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Technology Process of 2-(3-(2H-tetrazol-5-yl)propoxy)-5-chloro-N-(2-oxo-5-(2,4,6-trichlorophenyl)-2,3-dihydro-1-benzo[e][1,4]diazepin-3-yl)benzamide

There total 12 articles about 2-(3-(2H-tetrazol-5-yl)propoxy)-5-chloro-N-(2-oxo-5-(2,4,6-trichlorophenyl)-2,3-dihydro-1-benzo[e][1,4]diazepin-3-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1271524-67-4
3-amino-5-(2,4,6-trichloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one hydrochloride

: 1351763-22-8
2-(3-(2H-tetrazol-5-yl)propoxy)-5-chlorobenzoic acid

: 1351763-65-9
2-(3-(2H-tetrazol-5-yl)propoxy)-5-chloro-N-(2-oxo-5-(2,4,6-trichlorophenyl)-2,3-dihydro-1-benzo[e][1,4]diazepin-3-yl)benzamide

Guidance literature:: 2-(3-(2H-tetrazol-5-yl)propoxy)-5-chlorobenzoic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide;

3-amino-5-(2,4,6-trichloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 16512-74-6
1-(4-methoxybenzyl)-2H-benzo[d][1,3]oxazine-2,4(1H)-dione

: 1351763-65-9
2-(3-(2H-tetrazol-5-yl)propoxy)-5-chloro-N-(2-oxo-5-(2,4,6-trichlorophenyl)-2,3-dihydro-1-benzo[e][1,4]diazepin-3-yl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid / 24 h / 92 °C / Industry scale; Inert atmosphere

2.1: N,N-dimethyl-aniline; phosphorus trichloride / toluene / 16 h / 110 °C / Industry scale; Inert atmosphere

2.2: 25 °C / pH > 12

3.1: 2,4,6-Triisopropylbenzenesulfonyl azide; potassium tert-butylate / 2-methyltetrahydrofuran / 2.5 h / 40 - 50 °C / Inert atmosphere; 3 ? molecular sieve

3.2: 36 h / -20 - 30 °C / pH > 12

4.1: hydrogen / platinum(IV) oxide / 1,4-dioxane / 3 h / 7500.75 Torr / Industry scale; Autoclave

5.1: potassium carbonate; silver carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 72 h / Reflux

6.1: aluminum (III) chloride / methoxybenzene / 4 h / 70 °C

6.2: 2 h

7.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide

7.2: 20 °C

With aluminum (III) chloride; 2,4,6-Triisopropylbenzenesulfonyl azide; potassium tert-butylate; hydrogen; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N,N-dimethyl-aniline; triethylamine; silver carbonate; phosphorus trichloride; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; methoxybenzene; N,N-dimethyl-formamide; toluene;

Reference yield:

: 376584-34-8
2H-1,4-benzodiazepin-2-one, 5-chloro-1,3-dihydro-1-(4-methoxybenzyl)-

: 1351763-65-9
2-(3-(2H-tetrazol-5-yl)propoxy)-5-chloro-N-(2-oxo-5-(2,4,6-trichlorophenyl)-2,3-dihydro-1-benzo[e][1,4]diazepin-3-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2,4,6-Triisopropylbenzenesulfonyl azide; potassium tert-butylate / 2-methyltetrahydrofuran / 2.5 h / 40 - 50 °C / Inert atmosphere; 3 ? molecular sieve

1.2: 36 h / -20 - 30 °C / pH > 12

2.1: hydrogen / platinum(IV) oxide / 1,4-dioxane / 3 h / 7500.75 Torr / Industry scale; Autoclave

3.1: potassium carbonate; silver carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 72 h / Reflux

4.1: aluminum (III) chloride / methoxybenzene / 4 h / 70 °C

4.2: 2 h

5.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide

5.2: 20 °C

With aluminum (III) chloride; 2,4,6-Triisopropylbenzenesulfonyl azide; potassium tert-butylate; hydrogen; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; silver carbonate; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; methoxybenzene; N,N-dimethyl-formamide;