3-amino-5-(2,4,6-trichloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one hydrochloride

Base Information

Chemical Name:3-amino-5-(2,4,6-trichloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one hydrochloride
CAS No.:1271524-67-4
Molecular Formula:C₁₅H₁₀Cl₃N₃O
Molecular Weight:354.623
Hs Code.:

Synonyms:3-amino-5-(2,4,6-trichloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one hydrochloride

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Chemical Property of 3-amino-5-(2,4,6-trichloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one hydrochloride

Chemical Property:

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Technology Process of 3-amino-5-(2,4,6-trichloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one hydrochloride

There total 8 articles about 3-amino-5-(2,4,6-trichloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1271523-27-3
[1-(4-methoxy-benzyl)-2-oxo-5-(2,4,6-trichloro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester

: 1271524-67-4
3-amino-5-(2,4,6-trichloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one hydrochloride

Guidance literature:: [1-(4-methoxy-benzyl)-2-oxo-5-(2,4,6-trichloro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester; With aluminum (III) chloride; In methoxybenzene; at 70 ℃; for 4h;

With hydrogenchloride; In dichloromethane; for 2h;

Reference yield:

: 16512-74-6
1-(4-methoxybenzyl)-2H-benzo[d][1,3]oxazine-2,4(1H)-dione

: 1271524-67-4
3-amino-5-(2,4,6-trichloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid / 24 h / 92 °C / Industry scale; Inert atmosphere

2.1: N,N-dimethyl-aniline; phosphorus trichloride / toluene / 16 h / 110 °C / Industry scale; Inert atmosphere

2.2: 25 °C / pH > 12

3.1: 2,4,6-Triisopropylbenzenesulfonyl azide; potassium tert-butylate / 2-methyltetrahydrofuran / 2.5 h / 40 - 50 °C / Inert atmosphere; 3 ? molecular sieve

3.2: 36 h / -20 - 30 °C / pH > 12

4.1: hydrogen / platinum(IV) oxide / 1,4-dioxane / 3 h / 7500.75 Torr / Industry scale; Autoclave

5.1: potassium carbonate; silver carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 72 h / Reflux

6.1: aluminum (III) chloride / methoxybenzene / 4 h / 70 °C

6.2: 2 h

With aluminum (III) chloride; 2,4,6-Triisopropylbenzenesulfonyl azide; potassium tert-butylate; hydrogen; potassium carbonate; acetic acid; N,N-dimethyl-aniline; silver carbonate; phosphorus trichloride; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; methoxybenzene; toluene;

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 1271524-67-4
3-amino-5-(2,4,6-trichloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid / dichloromethane / 0.5 h / 40 °C / Industry scale; Inert atmosphere

1.2: 5 °C

2.1: tetrahydrofuran / 16 h / 15 - 20 °C

3.1: acetic acid / 24 h / 92 °C / Industry scale; Inert atmosphere

4.1: N,N-dimethyl-aniline; phosphorus trichloride / toluene / 16 h / 110 °C / Industry scale; Inert atmosphere

4.2: 25 °C / pH > 12

5.1: 2,4,6-Triisopropylbenzenesulfonyl azide; potassium tert-butylate / 2-methyltetrahydrofuran / 2.5 h / 40 - 50 °C / Inert atmosphere; 3 ? molecular sieve

5.2: 36 h / -20 - 30 °C / pH > 12

6.1: hydrogen / platinum(IV) oxide / 1,4-dioxane / 3 h / 7500.75 Torr / Industry scale; Autoclave

7.1: potassium carbonate; silver carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 72 h / Reflux

8.1: aluminum (III) chloride / methoxybenzene / 4 h / 70 °C

8.2: 2 h

With aluminum (III) chloride; 2,4,6-Triisopropylbenzenesulfonyl azide; potassium tert-butylate; hydrogen; potassium carbonate; acetic acid; N,N-dimethyl-aniline; silver carbonate; phosphorus trichloride; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; dichloromethane; methoxybenzene; toluene;