N-methyl-3-(3,4-dichlorophenyl)-3-phenylmethoxyazetidine hydrochloride

Base Information

Chemical Name:N-methyl-3-(3,4-dichlorophenyl)-3-phenylmethoxyazetidine hydrochloride
CAS No.:1447464-32-5
Molecular Formula:C₁₇H₁₇Cl₂NO*ClH
Molecular Weight:358.695
Hs Code.:

Synonyms:N-methyl-3-(3,4-dichlorophenyl)-3-phenylmethoxyazetidine hydrochloride

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Chemical Property of N-methyl-3-(3,4-dichlorophenyl)-3-phenylmethoxyazetidine hydrochloride

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Technology Process of N-methyl-3-(3,4-dichlorophenyl)-3-phenylmethoxyazetidine hydrochloride

There total 3 articles about N-methyl-3-(3,4-dichlorophenyl)-3-phenylmethoxyazetidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1-boc-3-(3,4-dichlorophenyl)-3-phenylmethoxyazetidine

: 1447464-32-5
N-methyl-3-(3,4-dichlorophenyl)-3-phenylmethoxyazetidine hydrochloride

Guidance literature:: 1-boc-3-(3,4-dichlorophenyl)-3-phenylmethoxyazetidine; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 15h; Inert atmosphere; Reflux;

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.05.071

Reference yield:

: 1447464-06-3
N-boc-3-(3,4-dichlorophenyl)-azetidin-3-ol

: 1447464-32-5
N-methyl-3-(3,4-dichlorophenyl)-3-phenylmethoxyazetidine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutylammomium bromide; sodium hydroxide / dichloromethane / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 15 h / 0 °C / Inert atmosphere; Reflux

2.2: 2 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; tetrabutylammomium bromide; sodium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2013.05.071

Reference yield:

: 18282-59-2
4-bromo-1,2-dichlorobenzene

: 1447464-32-5
N-methyl-3-(3,4-dichlorophenyl)-3-phenylmethoxyazetidine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1.17 h / -78 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

1.3: 20 °C / Inert atmosphere

2.1: tetrabutylammomium bromide; sodium hydroxide / dichloromethane / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 15 h / 0 °C / Inert atmosphere; Reflux

3.2: 2 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; n-butyllithium; tetrabutylammomium bromide; sodium hydroxide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.bmcl.2013.05.071