(5R,9R,13R,17R,21S)-2,2,5,9,13,17-hexamethyl-7,11,15,19-tetraoxo-3,3-diphenyl-21-(trifluoromethyl)-4,8,12,16,20-pentaoxa-3-silatricosan-23-oic acid

Base Information

Chemical Name:(5R,9R,13R,17R,21S)-2,2,5,9,13,17-hexamethyl-7,11,15,19-tetraoxo-3,3-diphenyl-21-(trifluoromethyl)-4,8,12,16,20-pentaoxa-3-silatricosan-23-oic acid
CAS No.:819852-34-1
Molecular Formula:C₃₆H₄₇F₃O₁₁Si
Molecular Weight:740.843
Hs Code.:

Synonyms:(5R,9R,13R,17R,21S)-2,2,5,9,13,17-hexamethyl-7,11,15,19-tetraoxo-3,3-diphenyl-21-(trifluoromethyl)-4,8,12,16,20-pentaoxa-3-silatricosan-23-oic acid

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Chemical Property of (5R,9R,13R,17R,21S)-2,2,5,9,13,17-hexamethyl-7,11,15,19-tetraoxo-3,3-diphenyl-21-(trifluoromethyl)-4,8,12,16,20-pentaoxa-3-silatricosan-23-oic acid

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Technology Process of (5R,9R,13R,17R,21S)-2,2,5,9,13,17-hexamethyl-7,11,15,19-tetraoxo-3,3-diphenyl-21-(trifluoromethyl)-4,8,12,16,20-pentaoxa-3-silatricosan-23-oic acid

There total 4 articles about (5R,9R,13R,17R,21S)-2,2,5,9,13,17-hexamethyl-7,11,15,19-tetraoxo-3,3-diphenyl-21-(trifluoromethyl)-4,8,12,16,20-pentaoxa-3-silatricosan-23-oic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 819852-32-9
(5R,9R,13R,17R,21S)-2,2,5,9,13,17-hexamethyl-7,11,15,19-tetraoxo-3,3-diphenyl-21-(trifluoromethyl)-4,8,12,16,20-pentaoxa-3-silatricosan-23-oic acid benzyl ester

: 819852-34-1
(5R,9R,13R,17R,21S)-2,2,5,9,13,17-hexamethyl-7,11,15,19-tetraoxo-3,3-diphenyl-21-(trifluoromethyl)-4,8,12,16,20-pentaoxa-3-silatricosan-23-oic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 18h;
DOI:10.1002/hlca.200490222

Reference yield:

: 178246-83-8
(R)-3-(tert-Butyl-diphenyl-silanyloxy)-butyric acid (R)-2-[(R)-2-((R)-2-carboxy-1-methyl-ethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethyl ester

: 819852-34-1
(5R,9R,13R,17R,21S)-2,2,5,9,13,17-hexamethyl-7,11,15,19-tetraoxo-3,3-diphenyl-21-(trifluoromethyl)-4,8,12,16,20-pentaoxa-3-silatricosan-23-oic acid

Guidance literature:: Multi-step reaction with 3 steps

1: (COCl)2; DMF / CH₂Cl₂ / 20 °C

2: 1.92 g / pyridine / CH₂Cl₂ / -78 - 20 °C

3: 98 percent / H₂ / Pd/C / methanol / 18 h

With pyridine; oxalyl dichloride; hydrogen; N,N-dimethyl-formamide; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1002/hlca.200490222

Reference yield:

: (R)-3-(tert-Butyl-diphenyl-silanyloxy)-butyric acid (R)-2-[(R)-2-((R)-2-chlorocarbonyl-1-methyl-ethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethyl ester

: 819852-34-1
(5R,9R,13R,17R,21S)-2,2,5,9,13,17-hexamethyl-7,11,15,19-tetraoxo-3,3-diphenyl-21-(trifluoromethyl)-4,8,12,16,20-pentaoxa-3-silatricosan-23-oic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.92 g / pyridine / CH₂Cl₂ / -78 - 20 °C

2: 98 percent / H₂ / Pd/C / methanol / 18 h

With pyridine; hydrogen; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1002/hlca.200490222