(5R,9R,13R,17R,21S)-2,2,5,9,13,17-hexamethyl-7,11,15,19-tetraoxo-3,3-diphenyl-21-(trifluoromethyl)-4,8,12,16,20-pentaoxa-3-silatricosan-23-oic acid benzyl ester

Base Information

Chemical Name:(5R,9R,13R,17R,21S)-2,2,5,9,13,17-hexamethyl-7,11,15,19-tetraoxo-3,3-diphenyl-21-(trifluoromethyl)-4,8,12,16,20-pentaoxa-3-silatricosan-23-oic acid benzyl ester
CAS No.:819852-32-9
Molecular Formula:C₄₃H₅₃F₃O₁₁Si
Molecular Weight:830.968
Hs Code.:

(5R,9R,13R,17R,21S)-2,2,5,9,13,17-hexamethyl-7,11,15,19-tetraoxo-3,3-diphenyl-21-(trifluoromethyl)-4,8,12,16,20-pentaoxa-3-silatricosan-23-oic acid benzyl ester

Synonyms:(5R,9R,13R,17R,21S)-2,2,5,9,13,17-hexamethyl-7,11,15,19-tetraoxo-3,3-diphenyl-21-(trifluoromethyl)-4,8,12,16,20-pentaoxa-3-silatricosan-23-oic acid benzyl ester

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Chemical Property of (5R,9R,13R,17R,21S)-2,2,5,9,13,17-hexamethyl-7,11,15,19-tetraoxo-3,3-diphenyl-21-(trifluoromethyl)-4,8,12,16,20-pentaoxa-3-silatricosan-23-oic acid benzyl ester

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Technology Process of (5R,9R,13R,17R,21S)-2,2,5,9,13,17-hexamethyl-7,11,15,19-tetraoxo-3,3-diphenyl-21-(trifluoromethyl)-4,8,12,16,20-pentaoxa-3-silatricosan-23-oic acid benzyl ester

There total 4 articles about (5R,9R,13R,17R,21S)-2,2,5,9,13,17-hexamethyl-7,11,15,19-tetraoxo-3,3-diphenyl-21-(trifluoromethyl)-4,8,12,16,20-pentaoxa-3-silatricosan-23-oic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 178246-82-7
(R)-3-(tert-Butyl-diphenyl-silanyloxy)-butyric acid (R)-2-[(R)-2-((R)-2-benzyloxycarbonyl-1-methyl-ethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethyl ester

: 819852-32-9
(5R,9R,13R,17R,21S)-2,2,5,9,13,17-hexamethyl-7,11,15,19-tetraoxo-3,3-diphenyl-21-(trifluoromethyl)-4,8,12,16,20-pentaoxa-3-silatricosan-23-oic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / 18 h

2: (COCl)2; DMF / CH₂Cl₂ / 20 °C

3: 1.92 g / pyridine / CH₂Cl₂ / -78 - 20 °C

With pyridine; oxalyl dichloride; hydrogen; N,N-dimethyl-formamide; palladium on activated charcoal; In dichloromethane;
DOI:10.1002/hlca.200490222

Reference yield:

: (R)-3-(tert-Butyl-diphenyl-silanyloxy)-butyric acid (R)-2-[(R)-2-((R)-2-chlorocarbonyl-1-methyl-ethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethyl ester

: 819852-25-0
(3S)-4,4,4-trifluoro-3-hydroxybutanoic acid benzyl ester

: 819852-32-9
(5R,9R,13R,17R,21S)-2,2,5,9,13,17-hexamethyl-7,11,15,19-tetraoxo-3,3-diphenyl-21-(trifluoromethyl)-4,8,12,16,20-pentaoxa-3-silatricosan-23-oic acid benzyl ester

Guidance literature:: With pyridine; In dichloromethane; at -78 - 20 ℃;
DOI:10.1002/hlca.200490222

Reference yield:

: 100-39-0
benzyl bromide

: 819852-32-9
(5R,9R,13R,17R,21S)-2,2,5,9,13,17-hexamethyl-7,11,15,19-tetraoxo-3,3-diphenyl-21-(trifluoromethyl)-4,8,12,16,20-pentaoxa-3-silatricosan-23-oic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / Na₂CO₃ / dimethylformamide / 12 h

2: 1.92 g / pyridine / CH₂Cl₂ / -78 - 20 °C

With pyridine; sodium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200490222