methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-6-bromo-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Base Information

Chemical Name:methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-6-bromo-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate
CAS No.:1336905-27-1
Molecular Formula:C₃₂H₃₇BrF₃N₃O₃
Molecular Weight:648.563
Hs Code.:

Synonyms:methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-6-bromo-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

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Chemical Property of methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-6-bromo-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

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Technology Process of methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-6-bromo-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

There total 7 articles about methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-6-bromo-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 4897-50-1
4-piperidinopiperidin

: 1336905-24-8
methyl 6-bromo-3-(bromomethyl)-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

: 1336905-27-1
methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-6-bromo-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: With potassium carbonate; In acetonitrile; for 2h; Product distribution / selectivity; Reflux;

Reference yield:

: 77337-82-7
1-bromo-2-methoxy-4-nitrobenzene

: 1336905-27-1
methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-6-bromo-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen bromide / water / 20 h / Reflux

2.1: potassium carbonate / acetonitrile / 2 h / Reflux

3.1: nickel(II) chloride tetrahydrate / acetonitrile / 0.08 h / 0 °C

3.2: 0.08 h / 0 °C

4.1: ethanol / 1 h / Reflux

4.2: 19 h / 20 °C / Reflux

5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h

5.2: 1 h / 20 °C

6.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 6 h / Reflux

7.1: potassium carbonate / acetonitrile / 2 h / Reflux

With N-Bromosuccinimide; oxalyl dichloride; hydrogen bromide; potassium carbonate; dibenzoyl peroxide; nickel(II) chloride tetrahydrate; N,N-dimethyl-formamide; In tetrachloromethane; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 52427-05-1
2-bromo-5-nitrophenol

: 1336905-27-1
methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-6-bromo-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / acetonitrile / 2 h / Reflux

2.1: nickel(II) chloride tetrahydrate / acetonitrile / 0.08 h / 0 °C

2.2: 0.08 h / 0 °C

3.1: ethanol / 1 h / Reflux

3.2: 19 h / 20 °C / Reflux

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h

4.2: 1 h / 20 °C

5.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 6 h / Reflux

6.1: potassium carbonate / acetonitrile / 2 h / Reflux

With N-Bromosuccinimide; oxalyl dichloride; potassium carbonate; dibenzoyl peroxide; nickel(II) chloride tetrahydrate; N,N-dimethyl-formamide; In tetrachloromethane; ethanol; dichloromethane; acetonitrile;