6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxylic acid

Base Information

Chemical Name:6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxylic acid
CAS No.:1204745-05-0
Molecular Formula:C₂₈H₂₁FO₆
Molecular Weight:472.47
Hs Code.:

Synonyms:6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxylic acid

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Chemical Property of 6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxylic acid

Chemical Property:

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Technology Process of 6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxylic acid

There total 5 articles about 6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1204745-07-2
methyl 6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxylate

: 1204745-05-0
6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxylic acid

Guidance literature:: methyl 6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxylate; With lithium hydroxide monohydrate; In tetrahydrofuran; at 70 ℃; for 3h;

Acidic conditions;
DOI:10.1002/anie.200904410

Reference yield:

: 6-bromo-2,2-bis-(4-methoxy-phenyl)-benzo[1,3]dioxole-4-carboxylic acid methyl ester

: 1204745-05-0
6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; water; toluene / 3 h / 100 °C / Inert atmosphere

2: lithium hydroxide monohydrate / 70 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; potassium carbonate; In ethanol; water; toluene; 1: Suzuki coupling;
DOI:10.1002/chem.201003648

Reference yield:

: 303-38-8
2,3-Dihydroxybenzoic acid

: 1204745-05-0
6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: bromine; acetic acid / 20 h / 20 °C / Inert atmosphere

2: thionyl chloride / 15 h / 65 °C / Inert atmosphere

3: oxalyl dichloride / 3 h / 60 - 160 °C / Inert atmosphere

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; water; toluene / 3 h / 100 °C / Inert atmosphere

5: lithium hydroxide monohydrate / 70 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; oxalyl dichloride; lithium hydroxide monohydrate; bromine; potassium carbonate; acetic acid; In ethanol; water; toluene; 4: Suzuki coupling;
DOI:10.1002/chem.201003648