methyl 6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxylate

Base Information

Chemical Name:methyl 6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxylate
CAS No.:1204745-07-2
Molecular Formula:C₂₉H₂₃FO₆
Molecular Weight:486.496
Hs Code.:

Synonyms:methyl 6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxylate

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Chemical Property of methyl 6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxylate

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Technology Process of methyl 6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxylate

There total 4 articles about methyl 6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 6-bromo-2,2-bis-(4-methoxy-phenyl)-benzo[1,3]dioxole-4-carboxylic acid methyl ester

: 1765-93-1
4-fluoroboronic acid

: 1204745-07-2
methyl 6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; water; toluene; at 100 ℃; for 3h; Inert atmosphere;
DOI:10.1002/chem.201003648

Reference yield:

: 303-38-8
2,3-Dihydroxybenzoic acid

: 1204745-07-2
methyl 6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: bromine; acetic acid / 20 h / 20 °C / Inert atmosphere

2: thionyl chloride / 15 h / 65 °C / Inert atmosphere

3: oxalyl dichloride / 3 h / 60 - 160 °C / Inert atmosphere

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; water; toluene / 3 h / 100 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; oxalyl dichloride; bromine; potassium carbonate; acetic acid; In ethanol; water; toluene; 4: Suzuki coupling;
DOI:10.1002/chem.201003648

Reference yield:

: 72517-15-8
2,3-dihydroxy-5-bromobenzoic acid

: 1204745-07-2
methyl 6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 15 h / 65 °C / Inert atmosphere

2: oxalyl dichloride / 3 h / 60 - 160 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; water; toluene / 3 h / 100 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; oxalyl dichloride; potassium carbonate; In ethanol; water; toluene; 3: Suzuki coupling;
DOI:10.1002/chem.201003648