(R)-methyl 2'-amino-1-benzyl-3'-cyano-2-oxospiro[indoline-3,4'-pyran]-6'-carboxylate

Base Information

Chemical Name:(R)-methyl 2'-amino-1-benzyl-3'-cyano-2-oxospiro[indoline-3,4'-pyran]-6'-carboxylate
CAS No.:1370462-65-9
Molecular Formula:C₂₂H₁₇N₃O₄
Molecular Weight:387.395
Hs Code.:

Synonyms:(R)-methyl 2'-amino-1-benzyl-3'-cyano-2-oxospiro[indoline-3,4'-pyran]-6'-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-methyl 2'-amino-1-benzyl-3'-cyano-2-oxospiro[indoline-3,4'-pyran]-6'-carboxylate

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Technology Process of (R)-methyl 2'-amino-1-benzyl-3'-cyano-2-oxospiro[indoline-3,4'-pyran]-6'-carboxylate

There total 1 articles about (R)-methyl 2'-amino-1-benzyl-3'-cyano-2-oxospiro[indoline-3,4'-pyran]-6'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 600-22-6
pyruvic acid methyl ester

: 59762-59-3
2-(1-benzyl-2-oxo-1,2-dihydro-indol-3-ylidene)malononitrile

: 1370462-65-9
(R)-methyl 2'-amino-1-benzyl-3'-cyano-2-oxospiro[indoline-3,4'-pyran]-6'-carboxylate

Guidance literature:: With 1-(((1R,4aS,10aR)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)methyl)-3-((1R)-(6-methoxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)-methyl)thiourea; In diethyl ether; at 20 ℃; for 12h; optical yield given as %ee; enantioselective reaction; Molecular sieve; Inert atmosphere;
DOI:10.1002/adsc.201100792