2,5-dimethyl-1-(2-phenylthiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid 4-aminomethyl-2,6-dimethylbenzylamide

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Chemical Name:2,5-dimethyl-1-(2-phenylthiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid 4-aminomethyl-2,6-dimethylbenzylamide
CAS No.:1618646-53-9
Molecular Formula:C₂₇H₃₀N₄OS
Molecular Weight:458.627
Hs Code.:

Synonyms:2,5-dimethyl-1-(2-phenylthiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid 4-aminomethyl-2,6-dimethylbenzylamide

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Chemical Property of 2,5-dimethyl-1-(2-phenylthiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid 4-aminomethyl-2,6-dimethylbenzylamide

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Technology Process of 2,5-dimethyl-1-(2-phenylthiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid 4-aminomethyl-2,6-dimethylbenzylamide

There total 6 articles about 2,5-dimethyl-1-(2-phenylthiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid 4-aminomethyl-2,6-dimethylbenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1618647-98-5
[4-({[2,5-dimethyl-1-(2-phenylthiazol-4-ylmethyl)-1H-pyrrole-3-carbonyl]amino}methyl)-3,5-dimethylbenzyl]carbamic acid tert-butyl ester

: 1618646-53-9
2,5-dimethyl-1-(2-phenylthiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid 4-aminomethyl-2,6-dimethylbenzylamide

Guidance literature:: With hydrogenchloride; water; In 1,4-dioxane; methanol; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1618647-84-9
1-[(2-phenylthiazol-4-yl)methyl]-2,5-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

: 1618646-53-9
2,5-dimethyl-1-(2-phenylthiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid 4-aminomethyl-2,6-dimethylbenzylamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; water / ethanol / 72 h / 90 °C / Inert atmosphere

2: benzotriazol-1-ol; triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

3: water; hydrogenchloride / methanol; 1,4-dioxane / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; water; benzotriazol-1-ol; triethylamine; sodium hydroxide; In 1,4-dioxane; methanol; ethanol; dichloromethane;

Reference yield:

: 1618647-94-1
(4-cyano-2,6-dimethylbenzyl)carbamic acid benzyl ester

: 1618646-53-9
2,5-dimethyl-1-(2-phenylthiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid 4-aminomethyl-2,6-dimethylbenzylamide

Guidance literature:: Multi-step reaction with 4 steps

1: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol / 72 h / 0 - 20 °C / Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / methanol / 1 h / 20 °C / 760.05 Torr

3: benzotriazol-1-ol; triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

4: water; hydrogenchloride / methanol; 1,4-dioxane / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; nickel(II) chloride hexahydrate; palladium 10% on activated carbon; water; hydrogen; benzotriazol-1-ol; triethylamine; In 1,4-dioxane; methanol; dichloromethane;