2-azido-1-methoxy-4-[1-(3,4,5-trimethoxyphenyl)vinyl]benzene

Base Information

• Chemical Name: 2-azido-1-methoxy-4-[1-(3,4,5-trimethoxyphenyl)vinyl]benzene
• CAS No.: 1353569-21-7
• Molecular Formula: C₁₈H₁₉N₃O₄
• Molecular Weight: 341.367
• Mol file: 1353569-21-7.mol

Synonyms:2-azido-1-methoxy-4-[1-(3,4,5-trimethoxyphenyl)vinyl]benzene

Chemical Property of 2-azido-1-methoxy-4-[1-(3,4,5-trimethoxyphenyl)vinyl]benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-azido-1-methoxy-4-[1-(3,4,5-trimethoxyphenyl)vinyl]benzene

There total 6 articles about 2-azido-1-methoxy-4-[1-(3,4,5-trimethoxyphenyl)vinyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-(3'-amino-4'-methoxyphenyl)-1-(3'',4'',5''-trimethoxyphenyl)ethylene (1070195-62-8) → 2-azido-1-methoxy-4-[1-(3,4,5-trimethoxyphenyl)vinyl]benzene (1353569-21-7)

Guidance literature:

1-(3'-amino-4'-methoxyphenyl)-1-(3'',4'',5''-trimethoxyphenyl)ethylene; With hydrogenchloride; In water; acetone; at 0 ℃; for 0.333333h;

With sodium nitrite; In water; acetone; for 0.333333h;

With sodium azide; In water; acetone; at 0 ℃; for 0.25h;

DOI:10.1002/cmdc.201100325

Reference yield:

C17H19IO5 (1353568-59-8) → 2-azido-1-methoxy-4-[1-(3,4,5-trimethoxyphenyl)vinyl]benzene (1353569-21-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridinium chlorochromate / dichloromethane / 12 h / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C

2.2: 1 h / 0 °C

3.1: copper(l) iodide; potassium ascorbate; sodium azide; N,N`-dimethylethylenediamine / water; dimethyl sulfoxide

With copper(l) iodide; sodium azide; potassium ascorbate; pyridinium chlorochromate; lithium hexamethyldisilazane; N,N`-dimethylethylenediamine; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; 2.2: Wittig reaction;

DOI:10.1002/cmdc.201100325

Reference yield:

(3-iodo-4-methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone → 2-azido-1-methoxy-4-[1-(3,4,5-trimethoxyphenyl)vinyl]benzene (1353569-21-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C

1.2: 1 h / 0 °C

2.1: copper(l) iodide; potassium ascorbate; sodium azide; N,N`-dimethylethylenediamine / water; dimethyl sulfoxide

With copper(l) iodide; sodium azide; potassium ascorbate; lithium hexamethyldisilazane; N,N`-dimethylethylenediamine; In tetrahydrofuran; water; dimethyl sulfoxide; 1.2: Wittig reaction;

DOI:10.1002/cmdc.201100325

upstream raw materials:

1-(3'-amino-4'-methoxyphenyl)-1-(3'',4'',5''-trimethoxyphenyl)ethylene

C₁₇H₁₉IO₅

3-iodo-4-methoxybenzaldehyde

Downstream raw materials:

1-{2-methoxy-5-[1-(3,4,5-trimethoxyphenyl)vinyl]phenyl}-4-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole

methyl 1-(2-methoxy-5-(1-(3,4,5-trimethoxyphenyl)vinyl)phenyl)-1H-1,2,3-triazole-4-carboxylate

1-{2-methoxy-5-[1-(3,4,5-trimethoxyphenyl)vinyl]phenyl}-4-(4-methoxyphenyl)-1H-1,2,3-triazole