(3R,4R)-tert-butyl 3-((6-(benzyl(tert-butoxycarbonyl)amino)pyridin-2-yl)methyl)-4-(2-(3-fluorophenethylamino)ethoxy)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(3R,4R)-tert-butyl 3-((6-(benzyl(tert-butoxycarbonyl)amino)pyridin-2-yl)methyl)-4-(2-(3-fluorophenethylamino)ethoxy)pyrrolidine-1-carboxylate
CAS No.:1258299-32-9
Molecular Formula:C₃₇H₄₉FN₄O₅
Molecular Weight:648.818
Hs Code.:

Synonyms:(3R,4R)-tert-butyl 3-((6-(benzyl(tert-butoxycarbonyl)amino)pyridin-2-yl)methyl)-4-(2-(3-fluorophenethylamino)ethoxy)pyrrolidine-1-carboxylate

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Chemical Property of (3R,4R)-tert-butyl 3-((6-(benzyl(tert-butoxycarbonyl)amino)pyridin-2-yl)methyl)-4-(2-(3-fluorophenethylamino)ethoxy)pyrrolidine-1-carboxylate

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Technology Process of (3R,4R)-tert-butyl 3-((6-(benzyl(tert-butoxycarbonyl)amino)pyridin-2-yl)methyl)-4-(2-(3-fluorophenethylamino)ethoxy)pyrrolidine-1-carboxylate

There total 1 articles about (3R,4R)-tert-butyl 3-((6-(benzyl(tert-butoxycarbonyl)amino)pyridin-2-yl)methyl)-4-(2-(3-fluorophenethylamino)ethoxy)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1258299-31-8
(3R,4R)-tert-butyl 3-((6-(benzyl(tert-butoxycarbonyl)amino)pyridin-2-yl)methyl)-4-(2-oxoethoxy)pyrrolidine-1-carboxylate

: 404-70-6
2-(3-Fluorophenyl)ethylamine

: 1258299-32-9
(3R,4R)-tert-butyl 3-((6-(benzyl(tert-butoxycarbonyl)amino)pyridin-2-yl)methyl)-4-(2-(3-fluorophenethylamino)ethoxy)pyrrolidine-1-carboxylate

Guidance literature:: With sodium tris(acetoxy)borohydride; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2010.08.096

Reference yield: 99.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1258299-32-9
(3R,4R)-tert-butyl 3-((6-(benzyl(tert-butoxycarbonyl)amino)pyridin-2-yl)methyl)-4-(2-(3-fluorophenethylamino)ethoxy)pyrrolidine-1-carboxylate

: 1258299-33-0
(3R,4R)-tert-butyl 3-((6-(benzyl(tert-butoxycarbonyl)amino)pyridin-2-yl)methyl)-4-(2-(tertbutoxycarbonyl-(3-fluorophenethyl)amino)ethoxy)pyrrolidine-1-carboxylate

Guidance literature:: With triethylamine; In methanol; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmcl.2010.08.096

Reference yield: 70.0%

: 1258299-32-9
(3R,4R)-tert-butyl 3-((6-(benzyl(tert-butoxycarbonyl)amino)pyridin-2-yl)methyl)-4-(2-(3-fluorophenethylamino)ethoxy)pyrrolidine-1-carboxylate

: N-(3-fluorophenethyl)-2-((3R,4R)-4-((6-iminopiperidin-2-yl)methyl)pyrrolidin-3-yloxy)ethanamine hydrochloride

Guidance literature:: With hydrogenchloride; 20 % Pd(OH)2/C; hydrogen; In ethanol; at 20 ℃; for 40h; under 29736.8 Torr;
DOI:10.1016/j.bmcl.2010.08.096