N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-4-methoxyphenyl)acrylamide trifluoroacetate

Base Information

Chemical Name:N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-4-methoxyphenyl)acrylamide trifluoroacetate
CAS No.:1431959-21-5
Molecular Formula:C₂HF₃O₂*C₂₀H₂₁N₅O₂S
Molecular Weight:509.509
Hs Code.:

Synonyms:N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-4-methoxyphenyl)acrylamide trifluoroacetate

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Chemical Property of N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-4-methoxyphenyl)acrylamide trifluoroacetate

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Technology Process of N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-4-methoxyphenyl)acrylamide trifluoroacetate

There total 4 articles about N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-4-methoxyphenyl)acrylamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431960-50-7
C₁₇H₁₉N₅OS

: 814-68-6,25189-84-8
acryloyl chloride

: 76-05-1
trifluoroacetic acid

: 1431959-21-5
N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-4-methoxyphenyl)acrylamide trifluoroacetate

Guidance literature:: C₁₇H₁₉N₅OS; acryloyl chloride; With triethylamine; In tetrahydrofuran; at -70 - 20 ℃; Inert atmosphere;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 888498-07-5
(1H-pyrrolo[2,3-b]pyridin-4-yl)methanamine

: 1431959-21-5
N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-4-methoxyphenyl)acrylamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; dmap / methanol / 0.5 h / 20 °C / Cooling with ice

1.2: 1.58 h / 20 °C / Cooling with ice

2.1: triethylamine / dichloromethane / 12 h / 20 °C

3.1: triethylamine / tetrahydrofuran / -70 - 20 °C / Inert atmosphere

With dmap; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 10496-75-0
2-methoxy-5-nitrobenzylnitrile

: 1431959-21-5
N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-4-methoxyphenyl)acrylamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; ammonium hydroxide / methanol / 3 h / 20 °C / 724.03 Torr

2: triethylamine / dichloromethane / 12 h / 20 °C

3: triethylamine / tetrahydrofuran / -70 - 20 °C / Inert atmosphere

With ammonium hydroxide; hydrogen; triethylamine; In tetrahydrofuran; methanol; dichloromethane;