[5-{[(tertbutoxycarbonyl)amino]methyl}-6-(2,2-dimethylpropyl)-2-ethyl-4-(4-methylphenyl)pyridin-3-yl]acetic acid

Base Information

Chemical Name:[5-{[(tertbutoxycarbonyl)amino]methyl}-6-(2,2-dimethylpropyl)-2-ethyl-4-(4-methylphenyl)pyridin-3-yl]acetic acid
CAS No.:907611-17-0
Molecular Formula:C₂₇H₃₈N₂O₄
Molecular Weight:454.61
Hs Code.:

Synonyms:[5-{[(tertbutoxycarbonyl)amino]methyl}-6-(2,2-dimethylpropyl)-2-ethyl-4-(4-methylphenyl)pyridin-3-yl]acetic acid

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Chemical Property of [5-{[(tertbutoxycarbonyl)amino]methyl}-6-(2,2-dimethylpropyl)-2-ethyl-4-(4-methylphenyl)pyridin-3-yl]acetic acid

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Technology Process of [5-{[(tertbutoxycarbonyl)amino]methyl}-6-(2,2-dimethylpropyl)-2-ethyl-4-(4-methylphenyl)pyridin-3-yl]acetic acid

There total 13 articles about [5-{[(tertbutoxycarbonyl)amino]methyl}-6-(2,2-dimethylpropyl)-2-ethyl-4-(4-methylphenyl)pyridin-3-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 907611-17-0
[5-{[(tertbutoxycarbonyl)amino]methyl}-6-(2,2-dimethylpropyl)-2-ethyl-4-(4-methylphenyl)pyridin-3-yl]acetic acid

Guidance literature:: tert-butyl {[5-(cyanomethyl)-2-(2,2-dimethylpropyl)-6-ethyl-4-(4-methylphenyl)pyridin-3-yl]methyl}carbamate; With hydrogenchloride; In water; at 90 ℃; for 24h;

di-tert-butyl dicarbonate; With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃; for 17h; pH=> 7;

With hydrogenchloride; In tetrahydrofuran; water; pH=< 7;

Reference yield: 94.0%

: tert-butyl {[5-(cyanomethyl)-2-(2,2-dimethylpropyl)-6-ethyl-4-(4-methylphenyl)pyridin-3-yl]methyl}carbamate

: 907611-17-0
[5-{[(tertbutoxycarbonyl)amino]methyl}-6-(2,2-dimethylpropyl)-2-ethyl-4-(4-methylphenyl)pyridin-3-yl]acetic acid

Guidance literature:: tert-butyl {[5-(cyanomethyl)-2-(2,2-dimethylpropyl)-6-ethyl-4-(4-methylphenyl)pyridin-3-yl]methyl}carbamate; With hydrogenchloride; In water; at 90 ℃; for 24h;

With di-tert-butyl dicarbonate; sodium hydroxide; In tetrahydrofuran; water; ethyl acetate; at 20 ℃; for 1h;
DOI:10.1021/jm101236h

Reference yield:

: 907611-35-2
[5-{[(tert-butoxycarbonyl)amino]methyl}-2-ethyl-4-(4-methylphenyl)-6-neopentylpyridin-3-yl]methyl methanesulfonate

: 907611-17-0
[5-{[(tertbutoxycarbonyl)amino]methyl}-6-(2,2-dimethylpropyl)-2-ethyl-4-(4-methylphenyl)pyridin-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran; acetonitrile / 1 h / 20 °C

2.1: hydrogenchloride / water / 24 h / 90 °C

2.2: 1 h / 20 °C

With hydrogenchloride; tetrabutyl ammonium fluoride; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/jm101236h