[5-{[(tert-butoxycarbonyl)amino]methyl}-2-ethyl-4-(4-methylphenyl)-6-neopentylpyridin-3-yl]methyl methanesulfonate

Base Information

Chemical Name:[5-{[(tert-butoxycarbonyl)amino]methyl}-2-ethyl-4-(4-methylphenyl)-6-neopentylpyridin-3-yl]methyl methanesulfonate
CAS No.:907611-35-2
Molecular Formula:C₂₇H₄₀N₂O₅S
Molecular Weight:504.691
Hs Code.:

Synonyms:[5-{[(tert-butoxycarbonyl)amino]methyl}-2-ethyl-4-(4-methylphenyl)-6-neopentylpyridin-3-yl]methyl methanesulfonate

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Chemical Property of [5-{[(tert-butoxycarbonyl)amino]methyl}-2-ethyl-4-(4-methylphenyl)-6-neopentylpyridin-3-yl]methyl methanesulfonate

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Technology Process of [5-{[(tert-butoxycarbonyl)amino]methyl}-2-ethyl-4-(4-methylphenyl)-6-neopentylpyridin-3-yl]methyl methanesulfonate

There total 10 articles about [5-{[(tert-butoxycarbonyl)amino]methyl}-2-ethyl-4-(4-methylphenyl)-6-neopentylpyridin-3-yl]methyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 907611-33-0
tert-butyl {[2-(2,2-dimethylpropyl)-6-ethyl-5-(hydroxymethyl)-4-(4-methylphenyl)pyridin-3-yl]methyl}carbamate

: 124-63-0
methanesulfonyl chloride

: 907611-35-2
[5-{[(tert-butoxycarbonyl)amino]methyl}-2-ethyl-4-(4-methylphenyl)-6-neopentylpyridin-3-yl]methyl methanesulfonate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

Reference yield:

: C₂₁H₃₀N₂O

: 907611-35-2
[5-{[(tert-butoxycarbonyl)amino]methyl}-2-ethyl-4-(4-methylphenyl)-6-neopentylpyridin-3-yl]methyl methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / tetrahydrofuran / 20 °C

2: triethylamine / tetrahydrofuran / 0.5 h / 0 °C

With triethylamine; sodium hydroxide; In tetrahydrofuran;
DOI:10.1021/jm101236h

Reference yield:

: 96798-17-3
5,5-dimethyl-3-oxohexanenitrile

: 907611-35-2
[5-{[(tert-butoxycarbonyl)amino]methyl}-2-ethyl-4-(4-methylphenyl)-6-neopentylpyridin-3-yl]methyl methanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: piperidine; acetic acid / toluene / 8 h / Reflux

2.1: acetic acid / 1 h / 80 °C

3.1: ammonium cerium (IV) nitrate / water; acetone

4.1: ammonia; hydrogen / tetrahydrofuran; methanol / 3750.38 Torr

5.1: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C

5.2: 0 - 20 °C

6.1: sodium hydroxide / tetrahydrofuran / 20 °C

7.1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C

With piperidine; ammonium cerium (IV) nitrate; ammonia; hydrogen; diisobutylaluminium hydride; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; water; acetone; toluene; 1.1: Knoevenagel condensation;
DOI:10.1021/jm101236h