(R_p)-(2-hydroxymethylphenyl)(phenyl)(trimethylsilylmethyl)phosphine-P-borane

Base Information

Chemical Name:(R_p)-(2-hydroxymethylphenyl)(phenyl)(trimethylsilylmethyl)phosphine-P-borane
CAS No.:1603830-72-3
Molecular Formula:C₁₇H₂₆BOPSi
Molecular Weight:316.263
Hs Code.:

(R<SUB>p</SUB>)-(2-hydroxymethylphenyl)(phenyl)(trimethylsilylmethyl)phosphine-P-borane

Synonyms:(R_p)-(2-hydroxymethylphenyl)(phenyl)(trimethylsilylmethyl)phosphine-P-borane

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Chemical Property of (R_p)-(2-hydroxymethylphenyl)(phenyl)(trimethylsilylmethyl)phosphine-P-borane

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Technology Process of (R_p)-(2-hydroxymethylphenyl)(phenyl)(trimethylsilylmethyl)phosphine-P-borane

There total 9 articles about (R_p)-(2-hydroxymethylphenyl)(phenyl)(trimethylsilylmethyl)phosphine-P-borane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₃₄BOPSi₂

: 1603830-72-3
(R_p)-(2-hydroxymethylphenyl)(phenyl)(trimethylsilylmethyl)phosphine-P-borane

Guidance literature:: With ammonium chloride; In tetrahydrofuran; water; at 20 ℃; for 3h; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol500970x

Reference yield:

: 18982-54-2
o-bromobenzyl alcohol

: 1603830-72-3
(R_p)-(2-hydroxymethylphenyl)(phenyl)(trimethylsilylmethyl)phosphine-P-borane

Guidance literature:: Multi-step reaction with 3 steps

1.1: sec.-butyllithium / diethyl ether / 1 h / -70 °C / Inert atmosphere

1.2: -70 - 20 °C / Inert atmosphere

2.1: sulfuric acid / methanol / 1.5 h / 20 °C / Inert atmosphere

3.1: N,N,N,N,-tetramethylethylenediamine / diethyl ether; pentane / 6.67 h / -78 - 0 °C / Inert atmosphere

With N,N,N,N,-tetramethylethylenediamine; sulfuric acid; sec.-butyllithium; In methanol; diethyl ether; pentane;
DOI:10.1021/ol500970x

Reference yield:

: (1R,2S)-2-(((S)-(2-(hydroxymethyl)phenyl)(phenyl)phosphino)(methyl)amino)-1-phenylpropan-1-ol borane

: 1603830-72-3
(R_p)-(2-hydroxymethylphenyl)(phenyl)(trimethylsilylmethyl)phosphine-P-borane

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / methanol / 1.5 h / 20 °C / Inert atmosphere

2: N,N,N,N,-tetramethylethylenediamine / diethyl ether; pentane / 6.67 h / -78 - 0 °C / Inert atmosphere

With N,N,N,N,-tetramethylethylenediamine; sulfuric acid; In methanol; diethyl ether; pentane;
DOI:10.1021/ol500970x