(R)-[2-azido-2-(2-fluoro-6-iodophenyl)ethoxy](tert-butyl)dimethylsilane

Base Information

Chemical Name:(R)-[2-azido-2-(2-fluoro-6-iodophenyl)ethoxy](tert-butyl)dimethylsilane
CAS No.:1402461-14-6
Molecular Formula:C₁₄H₂₁FIN₃OSi
Molecular Weight:421.329
Hs Code.:

Synonyms:(R)-[2-azido-2-(2-fluoro-6-iodophenyl)ethoxy](tert-butyl)dimethylsilane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-[2-azido-2-(2-fluoro-6-iodophenyl)ethoxy](tert-butyl)dimethylsilane

Chemical Property:

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Technology Process of (R)-[2-azido-2-(2-fluoro-6-iodophenyl)ethoxy](tert-butyl)dimethylsilane

There total 5 articles about (R)-[2-azido-2-(2-fluoro-6-iodophenyl)ethoxy](tert-butyl)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1402461-13-5
(S)-2-[(tert-butyldimethylsilyl)oxy]-1-(2-fluoro-6-iodophenyl)ethanol

: 1402461-14-6
(R)-[2-azido-2-(2-fluoro-6-iodophenyl)ethoxy](tert-butyl)dimethylsilane

Guidance literature:: With diphenyl phosphoryl azide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 0 ℃; for 5h; Inert atmosphere;
DOI:10.1002/anie.201205106

Reference yield:

: 146137-72-6
6-fluoro-2-iodobenzaldehyde

: 1402461-14-6
(R)-[2-azido-2-(2-fluoro-6-iodophenyl)ethoxy](tert-butyl)dimethylsilane

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,1,1,3,3,3-hexamethyl-disilazane; n-butyllithium / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

1.2: 24 h / 0 °C / Inert atmosphere

2.1: hydroquinidein 1,4-phthalazinediyl diether; potassium hexacyanoferrate(III); methanesulfonamide; osmium(VIII) oxide; potassium carbonate / water; tert-butyl alcohol / 24 h / 0 °C

3.1: dmap; triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

4.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 0.08 h / 0 °C / Inert atmosphere

4.2: 5 h / 0 °C / Inert atmosphere

With dmap; osmium(VIII) oxide; n-butyllithium; methanesulfonamide; potassium carbonate; hydroquinidein 1,4-phthalazinediyl diether; triethylamine; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane; potassium hexacyanoferrate(III); diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water; toluene; tert-butyl alcohol; 1.2: |Wittig Olefination / 2.1: |Sharpless Dihydroxylation / 4.1: |Mitsunobu Displacement / 4.2: |Mitsunobu Displacement;
DOI:10.1002/chem.201300687

Reference yield:

: 1-fluoro-3-iodo-2-vinylbenzene

: 1402461-14-6
(R)-[2-azido-2-(2-fluoro-6-iodophenyl)ethoxy](tert-butyl)dimethylsilane

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroquinidein 1,4-phthalazinediyl diether; potassium hexacyanoferrate(III); methanesulfonamide; osmium(VIII) oxide; potassium carbonate / water; tert-butyl alcohol / 24 h / 0 °C

2.1: dmap; triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

3.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 0.08 h / 0 °C / Inert atmosphere

3.2: 5 h / 0 °C / Inert atmosphere

With dmap; osmium(VIII) oxide; methanesulfonamide; potassium carbonate; hydroquinidein 1,4-phthalazinediyl diether; triethylamine; triphenylphosphine; potassium hexacyanoferrate(III); diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water; toluene; tert-butyl alcohol; 1.1: |Sharpless Dihydroxylation / 3.1: |Mitsunobu Displacement / 3.2: |Mitsunobu Displacement;
DOI:10.1002/chem.201300687