8-Methoxy-4-[(methyl-phenethyl-carbamoyl)-methyl]-naphthalene-2-carboxylic acid methyl ester

Base Information

Chemical Name:8-Methoxy-4-[(methyl-phenethyl-carbamoyl)-methyl]-naphthalene-2-carboxylic acid methyl ester
CAS No.:181259-10-9
Molecular Formula:C₂₄H₂₅NO₄
Molecular Weight:391.467
Hs Code.:

Synonyms:8-Methoxy-4-[(methyl-phenethyl-carbamoyl)-methyl]-naphthalene-2-carboxylic acid methyl ester

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Chemical Property of 8-Methoxy-4-[(methyl-phenethyl-carbamoyl)-methyl]-naphthalene-2-carboxylic acid methyl ester

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Technology Process of 8-Methoxy-4-[(methyl-phenethyl-carbamoyl)-methyl]-naphthalene-2-carboxylic acid methyl ester

There total 9 articles about 8-Methoxy-4-[(methyl-phenethyl-carbamoyl)-methyl]-naphthalene-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 181259-09-6
8-Hydroxy-4-[(methyl-phenethyl-carbamoyl)-methyl]-naphthalene-2-carboxylic acid methyl ester

: 74-88-4
methyl iodide

: 181259-10-9
8-Methoxy-4-[(methyl-phenethyl-carbamoyl)-methyl]-naphthalene-2-carboxylic acid methyl ester

Guidance literature:: With potassium carbonate; In butanone; for 18h; Heating;
DOI:10.1021/jm950699x

Reference yield:

: 144003-48-5
methyl 8-(phenylmethoxy)-4-vinyl-2-naphthalenecarboxylate

: 181259-10-9
8-Methoxy-4-[(methyl-phenethyl-carbamoyl)-methyl]-naphthalene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) 9-BBN, 2.) aq. H₂O₂ / 1.) THF, RT, 48 h, 2.) THF, from 0 deg C to RT, 2 h

2: CrO₃, H₂SO₄ / acetone / 38 h / 0 °C

3: CH₂Cl₂ / 1 h / Ambient temperature

4: 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h / Ambient temperature

5: 90 percent / H₂ / 10percent Pd/C / ethanol / 2.5 h / 1810.02 Torr

6: 100 percent / K₂CO₃ / butan-2-one / 18 h / Heating

With chromium(VI) oxide; dmap; 9-borabicyclo[3.3.1]nonane dimer; sulfuric acid; hydrogen; dihydrogen peroxide; potassium carbonate; palladium on activated charcoal; In ethanol; dichloromethane; acetone; butanone;
DOI:10.1021/jm950699x

Reference yield:

: 144003-46-3
methyl 4-hydroxy-8-(phenylmethoxy)-2-naphthalenecarboxylate

: 181259-10-9
8-Methoxy-4-[(methyl-phenethyl-carbamoyl)-methyl]-naphthalene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent / pyridine / CH₂Cl₂ / 1 h / 0 °C

2: 1.) LiCl, PdCl₂6H₅)3>2 / 1.) DMF, RT, 15 min, 2.) DMF, RT, 12 h

3: 1.) 9-BBN, 2.) aq. H₂O₂ / 1.) THF, RT, 48 h, 2.) THF, from 0 deg C to RT, 2 h

4: CrO₃, H₂SO₄ / acetone / 38 h / 0 °C

5: CH₂Cl₂ / 1 h / Ambient temperature

6: 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h / Ambient temperature

7: 90 percent / H₂ / 10percent Pd/C / ethanol / 2.5 h / 1810.02 Torr

8: 100 percent / K₂CO₃ / butan-2-one / 18 h / Heating

With pyridine; chromium(VI) oxide; dmap; bis-triphenylphosphine-palladium(II) chloride; 9-borabicyclo[3.3.1]nonane dimer; sulfuric acid; hydrogen; dihydrogen peroxide; potassium carbonate; lithium chloride; palladium on activated charcoal; In ethanol; dichloromethane; acetone; butanone;
DOI:10.1021/jm950699x